リセドロネートが卵巣摘出後骨量減少ラットの海綿骨および皮質骨におよぼす効果--アルファカルシドールとの比較
スポンサーリンク
概要
- 論文の詳細を見る
The purpose of the present study was to compare the therapeutic effects of risedronate (RIS) and alfacalcidol (ALF) on cancellous and cortical bone in ovariectomized osteopenic rats. Forty-two female Sprague-Dawley rats, 7 months of age, were randomized by the stratified weight method into six groups: the sham-operated control (Sham) group, and five ovariectomized groups: treated with vehicle, RIS (0.1, 1.0, or 2.5 mg/kg, p.o., daily), and ALF (0.5 μg/kg, p.o., daily). Treatment was started 6 weeks after surgery and continued for 6 weeks. Evaluation at 12 weeks after surgery revealed that ovariectomy (OVX) decreased the cancellous bone volume/total tissue volume (BV/TV) of the proximal tibial metaphysis as a result of an increase of the bone formation rate/bone surface (BFR/BS), BFR/BV, and eroded surface (ES/BS), while having no effect on the cortical area (Ct Ar) of the tibial diaphysis. OVX also decreased the maximum load of the femoral distal metaphysis, while having no effect on any mechanical property parameters of the femoral diaphysis. RIS (at all the doses) increased the BV/TV relative to the value in the OVX-Vehicle group, but the value was not restored to that observed in the Sham group. The effects of RIS (1.0 mg/kg and 2.5 mg/kg) were similar, and greater than those of RIS (0.1 mg/kg). ALF also increased the BV/TV relative to the OVX-Vehicle group, but the value was not restored to that observed in the Sham group, similar to the results of RIS (1.0 mg/kg and 2.5 mg/kg) treatment. The alterations of the structural parameters induced by RIS (at the doses) were attributable to suppression of the increase of ES/BS, BFR/BS, and BFR/BV. The alterations of the structural parameters induced by ALF were attributable to suppression of the increase of ES/BS and attenuation of the increase of BFR/BV, while the BFR/BS was maintained. ALF also increased the Ct Ar to beyond the value observed in the Sham group. RIS (at all the doses) had no effect on the mechanical properties of the femoral distal metaphysis, whereas ALF prevented the loss of the maximum load of the femoral distal metaphysis. Thus, the results of the present study show differential effects of RIS and ALF on cancellous and cortical bone in ovariectomized osteopenic rats.
- 社団法人 日本実験動物学会の論文
- 2006-07-01
著者
-
岩本 潤
Department of Orthopaedic Surgery, School of Medicine, Keio University
-
SATO Yoshihiro
Department of Materials Science and Engineering, Faculty of Engineering, Osaka University
-
Sato Yoshihiro
Mitate Hospital Fukuoka Jpn
-
Takeda Tsuyoshi
Department Of Geriatric Medicine Osaka University Graduate School Of Medicine
-
竹田 毅
Department of Sports Clinic, School of Medicine, Keio University
-
YEH James
Metabolism Laboratory, Department of Medicine, Winthrop-University Hospital
-
Iwamoto J
Institute For Integrated Sports Medicine Keio University School Of Medicine
-
Yeh James
Metabolism Laboratory Department Of Medicine Winthrop-university Hospital
-
YAMADA HARUMOTO
Department of Orthopaedic Surgery, Fujita Health University
-
Iwamoto Jun
Department Of Sports Medicine Keio University School Of Medicine
-
Iwamoto Jun
Department Of Orthopaedic Surgery School Of Medicine Keio University
-
SEKI Azusa
Hamri Corporation
-
TAKEDA Tsuyoshi
Institute for Integrated Sports Medicine, Keio University School of Medicine
-
Seki Azusa
Hamri Co. Ltd.
-
Takeda Tsuyoshi
Institute For Integrated Sports Medicine Keio University School Of Medicine
-
Yamada Harumoto
Department Of Orthopaedic Surgery Fujita Health University
-
Takeda Tsuyoshi
Department Of Electrical And Electronic Engineering Faculty Of Mining Akita University
-
Sato Yoshihiro
Department Of Materials Science And Engineering Faculty Of Engineering Osaka University
-
Sato Yuki
Department Of Integrated Biosciences Graduate School Of Frontier Sciences The University Of Tokyo
-
Sato Yoshihiro
Department Of Biochemistry Kyoritsu College Of Pharmacy
-
関 あずさ
Hamri Co., Ltd.
-
Sato Yoshihiro
Department of Applied Biological Science, Tokyo University of Science
関連論文
- The Japanese Society of Hypertension Committee for Guidelines for the Management of Hypertension
- Effect of Increased Physical Activity on Bone Mineral Density in Postmenopausal Osteoporotic Women
- Effects of Static Magnetic Field and Hydrostatic Pressure on the Isothermal Martensitic Transformation in an Fe-Ni-Cr Alloy
- 成長期における detraining が骨量におよぼす影響に関する実験的研究
- Comparison of Arterial Functional Evaluations as a Predictor of Cardiovascular Events in Hypertensive Patients : The Non-Invasive Atherosclerotic Evaluation in Hypertension (NOAH) Study
- Renal Protective Effect in Hypertensive Patients : The High Doses of Angiotensin II Receptor Blocker (HARB) Study
- Renal-Protective Effect of T- and L-Type Calcium Channel Blockers in Hypertensive Patients : An Amlodipine-to-Benidipine Changeover (ABC) Study
- High blood pressure worsens age-related increases in arterial stiffness evaluated by pulse wave velocity in subjects with lifestyle-related diseases
- β3-Adrenergic Receptor Trp64arg Polymorphism Is Related with Endothelial Dysfunction via Increased Oxidized Stress in Proportion to Increasing Sympathetic Nervous Activity
- Prevalence and Lifestyle Characteristics of Hypertensive Patients with Metabolic Syndrome Followed at an Outpatient Clinic in Fukuoka, Japan
- Long-Term Compliance with Salt Restriction in Japanese Hypertensive Patients
- Relationship between the Awareness of Salt Restriction and the Actual Salt Intake in Hypertensive Patients
- 月状骨に生じた Osteochondral Fracture の治療経験
- Clinical Usefulness and Limitations of Brachial-Ankle Pulse Wave Velocity in the Evaluation of Cardiovascular Complications in Hypertensive Patients
- Evaluation of Morning Blood Pressure Elevation and Autonomic Nervous Activity in Hypertensive Patients Using Wavelet Transform of Heart Rate Variability
- Genetic Influences of β-Adrenoceptor Polymorphisms on Arterial Functional Changes and Cardiac Remodeling in Hypertensive Patients
- ラットにおける卵巣摘出術前後のリセドロネート投与が海綿骨量減少におよぼす影響
- Effects of Magnetic Field on Athermal and Isothermal Martensitic Transformations in Fe-Ni-Cr Alloys
- PJ-414 Prevention of Hypertensive Renal Complication by Monotherapy or Combination of Angiotensin AT1 Receptor Blocker and Sympathetic Antagonists in SHR/Izm.(Kidney/Renal Circulation 2 (H) : PJ69)(Poster Session (Japanese))
- Improvement of Blood Pressure Control in Hypertensive Patients with Renal Diseases
- A Case of Gitelman's Syndrome with Decreased Angiotensin II-Forming Activity
- Effect of exercise on tibial and lumbar vertebral bone mass in mature osteopenic rats:Bone histomorphometry study
- Stress fractures in athletes : review of 196 cases
- Insufficiency fracture of the femoral neck during osteoporosis treatment : a case report
- Effect of surgical treatment on physical activity and bone resorption in patients with neurogenic intermittent claudication
- Blood Pressure Control in Hypertensive Patients With a History of Stroke
- Radiographic Abnormalities of the Inferior Pole of the Patella in Juvenile Athletes
- Beneficial Effects of Combined Administration of Alendronate and Alfacalcidol on Cancellous Bone Mass of the Tibia in Orchidectomized Rats : A Bone Histomorphometry Study
- Muscle Strain of the Subscapularis Muscle : A Case Report
- Effects of Alfacalcidol on Cancellous and Cortical Bone Mass in Rats Treated with Glucocorticoid : A Bone Histomorphometry Study
- Effect of whole-body vibration exercise and muscle strengthening, balance, and walking exercises on walking ability in the elderly
- Additive Effect of Vitamin K2 and Risedronate on Long Bone Mass in Hypophysectomized Young Rats
- Effect of Risedronate on the Cortical and Cancellous Bone Mass and Mechanical Properties in Ovariectomized Rats : A Comparison with the Effects of Alfacalcidol
- Beneficial Effect of Pretreatment and Treatment Continuation with Risedronate and Vitamin K_2 on Cancellous Bone Loss after Ovariectomy in Rats : A Bone Histomorphometry Study
- アレンドロネートとアルファカルシドールが卵巣摘出ラットの海綿骨および皮質骨の骨量と骨強度におよぼす効果
- リセドロネートおよびカルシトリオールが高用量のグルココルチコイド投与ラットの海綿骨におよぼす影響
- リセドロネートが卵巣摘出後骨量減少ラットの海綿骨および皮質骨におよぼす効果--アルファカルシドールとの比較
- Comparative Effects of Risedronate and Calcitriol on Cancellous Bone in Rats with Glucocorticoid-Induced Osteopenia
- Comparative Therapeutic Effects of Alendronate and Alfacalcidol on Cancellous and Cortical Bone Mass and Mechanical Properties in Ovariectomized Osteopenic Rats
- Effects of risedronate on femoral bone mineral density and bone strength in sciatic neurectomized young rats
- Comparative Effects of Vitamin K and Vitamin D Supplementation on Calcium Balance in Young Rats Fed Normal or Low Calcium Diets
- Interventions to prevent bone loss in astronauts during space flight
- Effect of Treadmill Exercise on Bone Mass in Female Rats
- Effect of treatment with alendronate in osteogenesis imperfecta type I : a case report
- Effect of walking exercise on bone metabolism in postmenopausal women with osteopenia/osteoporosis
- Response of Cortical and Cancellous Bones to Mild Calcium Deficiency in Young Growing Female Rats : A Bone Histomorphometry Study
- Possible Linkage between Renal Injury and Cardiac Remodeling in Dahl Salt-Sensitive Rats Treated with the Calcium Channel Antagonist Benidipine
- Effects of Valsartan on the Progression of Chronic Renal Insufficiency in Patients with Nondiabetic Renal Diseases
- A case of melorheostosis with linear sclerodermatous skin changes
- Report of the Working Group for Dietary Salt Reduction of the Japanese Society of Hypertension : (1) Rationale for Salt Restriction and Salt-Restriction Target Level for the Management of Hypertension
- Central Cardiovascular Action of Urotensin II in Spontaneously Hypertensive Rats
- Analyses of Differential Gene Expression in Genetic Hypertensive Rats by Microarray
- Report of the Working Group for Dietary Salt Reduction of the Japanese Society of Hypertension : (2) Assessment of Salt Intake in the Management of Hypertension
- Predictive Significance of Blood Pressure Values for the Incidence of Cardiovascular Events in Chronic Hemodialysis Patients
- PE-105 Influence of Anemia and Inflammation on the Risks of Death and Cardiovascular Events in Chronic Hemodialysis Patients(Kidney/Renal circulation(03)(H),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Effects of treadmill exercise on bone mass, bone metabolism, and calciotropic hormones in young growing rats
- Comparative effects of orchidectomy and sciatic neurectomy on cortical and cancellous bone in young growing rats
- Efonidipine Reduces Proteinuria and Plasma Aldosterone in Patients with Chronic Glomerulonephritis
- -0266-MECHANISMS OF PREVENTING VENIRICULAR TACHYARRHYTHMIAS BY PROPRANOLOL : COMPARISON WITH A SYMPATHECTOMY MODEL
- -0264-SYMPATHETIC INNERVATION OF THE ANTEROLATERAL SURFACE OF THE LEFT VENTRICLE
- -0263-EFFICACY OF ANTIARRHYTHMIC AGENTS THEIR EFFECTS ON ERP DISPERSION
- Usefulness of the α_1-Blocker Doxazosin as a Third-Line Antihypertensive Drug
- β-Sitosteryl (6’-O-linoleoyl)-glucoside of Soybean (Glycine max L.) Crude Extract Inhibits Y-Family DNA Polymerases
- Effect of decreased physical activity on bone mass in exercise-trained young rats
- Nucleotide Sequences and Organization of the Genes for Carotovoricin (Ctv) from Erwinia carotovora Indicate That Ctv Evolved from the Same Ancestor as Salmonella typhi Prophage
- Antibacterial Properties of Metallic Elements for Alloying Evaluated with Application of JIS Z 2801:2000
- Effect of alendronate on bone mineral density and bone turnover markers in post-gastrectomy osteoporotic patients
- Role of sport and exercise in the maintenance of female bone health
- Effects of magnetic field on athermal and isothermal martensitic transformations in Fe-Ni-Cr alloys
- Effects of Static Magnetic Field and Hydrostatic Pressure on the Isothermal Martensitic Transformation in an Fe-Ni-Cr Alloy
- Differential effect of short-term etidronate treatment on three cancellous bone sites in orchidectomized adult rats
- Comparative effects of treatment with etidronate and alendronate on bone resorption, back pain, and activities of daily living in elderly women with vertebral fractures
- Treatment with vitamin D_3 and/or vitamin K_2 for postmenopausal osteoporosis
- Effects of cyclical etidronate with alfacalcidol on lumbar bone mineral density, bone resorption, and back pain in postmenopausal women with osteoporosis
- Early response to alendronate after treatment with etidronate in postmenopausal women with osteoporosis
- Effects of treatment with etidronate and alfacalcidol for osteogenesis imperfecta type I : a case report
- Effects of 5-year treatment with elcatonin and alfacalcidol on lumbar bone mineral density and the incidence of vertebral fractures in postmenopausal women with osteoporosis : a retrospective study
- Forearm bone mineral density in patients with rheumatoid arthritis
- Transient relief of metastatic cancer bone pain by oral administration of etidronate
- Increased bone resorption with decreased activity and increased recruitment of osteoblasts in osteogenesis imperfecta type I
- Forearm bone mineral density in postmenopausal women with osteoarthritis of the knee
- Relationships among physical activity, metacarpal bone mass, and bone resorption marker in 70 healthy adult males
- Effect of menatetrenone on bone mineral density and incidence of vertebral fractures in postmenopausal women with osteoporosis : a comparison with the effect of etidronate
- Effect of administration of lipoprostaglandin E_1 on physical activity and bone resorption in patients with neurogenic intermittent claudication
- Relationships between physical activity and metacarpal cortical bone mass and bone resorption in hemiplegic patients
- Effect of exercise training and detraining on bone mineral density in postmenopausal women with osteoporosis
- Effects of the Ethyl and Benzyl Ethers of Indenestrols A and B on Cytotoxicity in Chinese Hamster V79 Cells
- Absorption of Oxygen into Iron Weld Metal during Arc Welding
- Urinary levels of cross-linked N-terminal telopeptide of type I collagen and nutritional status in Japanese professional baseball players
- Cloning and Expression of Cytochrome P450 Genes, Belonging to a New P450 Family, of the Basidiomycete Lentinula edodes(Biochemistry & Molecular Biology)
- Long Terminal Repeat of the Mushroom Retrotransposon Functions as a Dual Terminator to Transcription
- Nitrogen Absorption by Iron and Stainless Steels during YAG Laser Welding
- Oxygen Absorption and Oxide Inclusion of Iron Weld Metal during Arc Welding
- Efficacy of training program for ambulatory competence in elderly women
- Comparative effects of intermittent administration of human parathyroid hormone (1-34) on cancellous and cortical bone loss in tail-suspended and sciatic neurectomized young rats
- Effects of Moderate Intensity Exercise on Tibial Bone Mass in Mature Ovariectomized Rats : Bone Histomorphometry Study
- Oxygen Absorption in Iron and Steel Weld Metal
- Rate of Complex Formation and Solvent Extraction of Chromium(III) Produced by the Reduction of Chromium(VI) with Acetylacetone in Aqueous Solutions
- Japan Renal Biopsy Registry : the first nationwide, web-based, and prospective registry system of renal biopsies in Japan
- Does a Combination Pill of Antihypertensive Drugs Improve Medication Adherence in Japanese? : A Randomized Controlled Trial