Effect of Risedronate on the Cortical and Cancellous Bone Mass and Mechanical Properties in Ovariectomized Rats : A Comparison with the Effects of Alfacalcidol

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概要

• 論文の詳細を見る

• The purpose of the present study was to compare the effects of risedronate (RIS) and alfacalcidol (ALF) on the cortical and cancellous bone mass and mechanical properties in ovariectomized rats in a head-to-head fashion. Forty female Sprague-Dawley rats, 7 mo of age, were randomized into six groups: the sham-operated control (Sham) group, and five ovariectomized groups: treated with vehicle, RIS (0.1, 1.0, or 2.5mg/kg, p.o., daily), and ALF (0.5μg/kg, p.o., daily). At the end of the 8-wk experimental period, bone histomorphometric analyses of the cancellous bone of the proximal tibial metaphysis and cortical bone of the tibial disphysis was performed, and the mechanical properties of the bone were evaluated at the femoral distal metaphysis (FDM) and femoral diaphysis (FD). RIS prevented the decrease in the cancellous bone volume/total tissue volume (BV/TV) noted in ovariectomized rats in a dose-dependent manner, by suppressing increases in cancellous bone formation and resorption, without any apparent effect on the Ct Ar or maximum load of the FDM or FD. On the other hand, ALF increased the cancellous BV/TV, Ct Ar, and maximum load of the FDM or FD, by mildly decreasing cancellous bone formation and resorption, increasing periosteal and endocortical bone formation, and preventing an increase in endocortical bone resorption. Thus, the present study clearly showed that RIS and ALF had differential effects on the cortical and cancellous bone mass and mechanical properties in ovariectomized rats.

• 日本ビタミン学会の論文

著者

• SATO Yoshihiro

  Department of Materials Science and Engineering, Faculty of Engineering, Osaka University

• Sato Yoshihiro

  Mitate Hospital Fukuoka Jpn

• Takeda Tsuyoshi

  Department Of Geriatric Medicine Osaka University Graduate School Of Medicine

• YEH James

  Metabolism Laboratory, Department of Medicine, Winthrop-University Hospital

• Iwamoto J

  Institute For Integrated Sports Medicine Keio University School Of Medicine

• Yeh James

  Metabolism Laboratory Department Of Medicine Winthrop-university Hospital

• YAMADA HARUMOTO

  Department of Orthopaedic Surgery, Fujita Health University

• Iwamoto Jun

  Department Of Sports Medicine Keio University School Of Medicine

• Iwamoto Jun

  Department Of Orthopaedic Surgery School Of Medicine Keio University

• SEKI Azusa

  Hamri Corporation

• TAKEDA Tsuyoshi

  Institute for Integrated Sports Medicine, Keio University School of Medicine

• Seki Azusa

  Hamri Co. Ltd.

• Takeda Tsuyoshi

  Institute For Integrated Sports Medicine Keio University School Of Medicine

• Yamada Harumoto

  Department Of Orthopaedic Surgery Fujita Health University

• Takeda Tsuyoshi

  Department Of Electrical And Electronic Engineering Faculty Of Mining Akita University

• Sato Yoshihiro

  Department Of Materials Science And Engineering Faculty Of Engineering Osaka University

• Sato Yuki

  Department Of Integrated Biosciences Graduate School Of Frontier Sciences The University Of Tokyo

• Sato Yoshihiro

  Department Of Biochemistry Kyoritsu College Of Pharmacy

• Sato Yoshihiro

  Department of Applied Biological Science, Tokyo University of Science

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