Antibacterial Properties of Metallic Elements for Alloying Evaluated with Application of JIS Z 2801:2000
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概要
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Antibacterial properties of 21 metallic elements used as alloying elements (Al, Si, Ti, V, Cr, Mn, Co, Ni, Cu, Zn, Zr, Nb, Mo, Pd, Ag, Sn, Ta, W, Pb, Au, Pt) was studied. Escherichia coli (Gram-negative bacteria) and Staphylococcus aureus subsp. aureus (Gram-positive bacteria) were used as model bacteria. The film attachment method was adopted for evaluation of antibacterial activity, and Japan industrial standard Z 2801:2000 was applied as the criterion for evaluate antimicrobial abilities of samples. Silver and Cu showed strong bactericidal effects as expected, and following them Co, Ni and Al were moderately toxic. Physiological effects of metals depended on the specie of bacteria. For example, Ni decreased the total viable count of E. coli to 10 cfu/mL in 4 h, while it took 24 h to decrease the total viable count of S. aureus. By judgment following to JIS Z 2801:2000, Pt and Pb were effective only for E. coli, while V and Zr were only for S. aureus. Gold was not toxic even though Au3+ had been reported as strong toxic. Also Mo showed antibacterial effects which can be resulting from decrease in pH of the bacteria suspension.
- 2008-09-15
著者
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SATO Yoshihiro
Department of Materials Science and Engineering, Faculty of Engineering, Osaka University
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KAWAKAMI HIROSHI
Department of Gastroenterology, Hokkaido University Graduate School of Medicine
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KIKUCHI Yasushi
Department of Experimental Pathology, Cancer Institute, Japanese Foundation for Cancer Research
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Kikuchi Yasushi
Department Of Experimental Pathology Cancer Institute Japanese Foundation For Cancer Research
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Yoshida Kazuki
Department Of Chemistry And Biotechnology Yokohama National University
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Yoshida Kazuki
Department Of Mechanical Engineering Osaka City University
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NISHIDA Yuya
Department of Mechanical Engineering, Osaka City University
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Kikuchi Yasushi
Graduate School Of Engineering Osaka City University
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KAWAKAMI Hiroshi
Graduate School of Engineering, Osaka City University
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Nishida Yuya
Department Of Mechanical Engineering Osaka City University
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Sato Yoshihiro
Department Of Materials Science And Engineering Faculty Of Engineering Osaka University
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Sato Yoshihiro
Graduate School Of Engineering Osaka City University
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Kawakami Hiroshi
Department Of Gastroenterology Hokkaido University Graduate School Of Medicine
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Sato Yoshihiro
Department Of Biochemistry Kyoritsu College Of Pharmacy
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Kawakami Hiroshi
Department Of Gastroenterology And Hepatology Hokkaido University
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Sato Yoshihiro
Department of Applied Biological Science, Tokyo University of Science
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YOSHIDA Kazuki
Department of Applied Physics, Tohoku University
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Kawakami Hiroshi
Department of Food Science & Nutrition, Kyoritsu Women's University
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Kawakami Hiroshi
Department of Cardiology, Ehime Prefectural Central Hospital
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