Clinical Efficacy of the Transdermal Tulobuterol Patch in Patients with Chronic Obstructive Pulmonary Disease: A Comparison with Slow-Release Theophylline
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概要
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Background There is insufficient evidence for the efficacy of a transdermal tulobuterol patch (TP), although combination therapy with bronchodilators is recommended for chronic obstructive pulmonary disease (COPD). Objective A randomized, controlled crossover study was conducted to evaluate the clinical efficacy and safety of the TP in 16 patients with COPD. Slow-release theophylline was used as a control drug. Methods Following a 2-week run-in period, patients were randomly allocated to two groups by the envelope method; they then received the TP and theophylline for 4 weeks each by the crossover method. Pulmonary function tests, peripheral blood examination, and electrocardiography were performed before and after each treatment period. Patients recorded in diaries their symptom scores, numbers of administrations of inhaled β2 agonists, and presence/absence of adverse reactions. Results Patients receiving TP exhibited significant improvement in the number and ease of sputum expectorations and in cough frequency score and wheezing severity score compared with baseline (p<0.05); the corresponding improvement in patients receiving theophylline was non-significant. Assessment of quality of life by the St. George's Hospital Respiratory Questionnaire revealed that treatment with TP was associated with significant improvement in symptoms, impact, and total scores compared with baseline (p<0.05); theophylline gave only a non-significant improvement in total score. Neither drug caused significant changes in the results of physiological examinations or in pulse or blood pressure. There was no difference in safety between the treatments. Conclusion Treatment of COPD patients with TP is more effective than with theophylline.
- 社団法人 日本内科学会の論文
著者
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Aizawa Hisamichi
Division Of Respirology Neurology And Rheumatology Department Of Internal Medicine Kurume University
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GOHARA Rumi
Division of Biopolymer Research, Department of Biomolecular Sciences, Faculty of Medicine, Saga Univ
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Iwanaga Tomoaki
Division of Respirology, Neurology, and Rheumatology, Department of Medicine, Kurume University School of Medicine
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KAWAYAMA TOMOTAKA
Division of Respiratory Medicine, Social Insurance Tagawa Hospital
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Minami Shuwa
Division of Respirology, Neurology, and Rheumatology, Department of Medicine, Kurume University School of Medicine
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Ichiki Masao
Division of Respirology, Neurology, and Rheumatology, Department of Medicine, Kurume University School of Medicine
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Nishiyama Mamoru
Division of Respirology, Neurology, and Rheumatology, Department of Medicine, Kurume University School of Medicine
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Sueyasu Yoshiko
Division of Respirology, Neurology, and Rheumatology, Department of Medicine, Kurume University School of Medicine
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Kinoshita Masaharu
Division of Respirology, Neurology, and Rheumatology, Department of Medicine, Kurume University School of Medicine
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Koga Hideyuki
Division of Respirology, Neurology, and Rheumatology, Department of Medicine, Kurume University School of Medicine
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