Effects of Indomethacin and Hyperventilation on Cerebral Hemodynamics and Oxygenation in Newborn Piglets
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概要
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We investigated the effect of indomethacin (INDO) and hyperventilaton (HV) on cerebral hemodynamics and oxygenation in newborn piglets using near-infrared spectroscopy (NIRS). A total of 10 piglets aged 7-10 days were divided into 2 groups. INDO (Experimental group; 0.2 mg/kg IV) or saline (Control group) was administered after steady state, then each group was hyperventilated (pCO<SUB>2</SUB>; 20 mm Hg). Cerebral oxyhemoglobin concentrations (HbO<SUB>2</SUB>) significantly decreased immediately after INDO administration compared to controls (p<0.01). This decrease continued for 15 min. During HV, HbO<SUB>2</SUB> remained low compared to the steady state (p<0.05) in the experimental group. Total hemoglobin concentrations (HbT) decreased simultaneously with HbO<SUB>2</SUB>. In the control group, no changes in HbO<SUB>2</SUB> or HbT were observed after saline administration, and only a slight decrease in HbO<SUB>2</SUB> was observed during the 5 minutes HV compared to the steady state. No changes in cytochrome aa3 (Cytaa3) were observed in either group during 100% O<SUB>2</SUB> inhalation. We conclude that INDO decreased HbO<SUB>2</SUB> and HbT by vasoconstriction, but that HV did not further aggravate this tendency. Great care should be taken when using INDO for newborn neonates.
著者
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Togo Akiko
Department Of Pediatrics And Child Health Kurume University School Of Medicine
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Yamashita Yushiro
Department Of Pediatrics & Child Health Kurume University School Of Medicine
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Murakami Yoshihiko
Department Of Chemical Engineering Waseda University
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Wada Naoko
Department Of Agricultural Chemistry Faculty Of Agriculture Kyoto University
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Kato Hirohisa
Department Of Cardiovascular Medicine National Center For Child Health And Development
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MATSUISHI Toyojiro
Department of Pediatrics & Child Health, Kurume University School of Medicine
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