Changes of Cerebral Hemodynamics and Oxygenation in Unstable Septic Newborns during Exchange Transfusion.
スポンサーリンク
概要
- 論文の詳細を見る
We investigated the effect of a two-way exchange transfusion on cerebral hemodynamics and oxygenation in 3 neonates using near infrared spectroscopy (NIBS). A total of 4 exchange transfusions (ET) for the treatment of sepsis were performed. Cerebral oxyhemoglobin concentrations (HbO<SUB>2</SUB>) increased immediately after commencing with ET by 8.82±3.46 (mean±SD)μmol/l, which persisted throughout the ET. Total hemoglobin concentrations (HbT) simultaneously increased by 8.92±3.81 (mean±SD)μmol/l. No changes in cerebral deoxyhemoglobin concentrations (HbR) and cytochrome aa<SUB>3</SUB> (Cytaa<SUB>3</SUB>) were observed. In one occasion, however, HbR increased markedly and HbO<SUB>2</SUB> decreased immediately after ET had begun, thus HbT remained slightly increased compared to the 3 other occasions. The extension of periventricular echogenecity was observed after ET by cranial ultrasound scan in this patient and periventricular leukomalacia was confirmed by autopsy. We conclude that a two-way exchange transfusion increases cerebral blood volume and improves cerebral oxygen delivery. Furthermore NIBS was useful in monitoring changes in cerebral hemodynamics and oxygenation in unstable septic neonates.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
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Yamashita Yushiro
Department Of Pediatrics & Child Health Kurume University School Of Medicine
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Inoue Toshiro
Department Of Bioscience And Technology Faculty Of Agriculture Iwate University
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Murakami Yoshihiko
Department Of Chemical Engineering Waseda University
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Kato Hirohisa
Department Of Cardiovascular Medicine National Center For Child Health And Development
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MATSUISHI Toyojiro
Department of Pediatrics & Child Health, Kurume University School of Medicine
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NISHIMI TOSHIHIRO
Department of Pediatrics and Child Health, Kurume University School of Medicine
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