Synthesis of Novel Trifluoromethyl-bearing Bifunctional Acyl-acceptant Arenes: 2,2’-Bis(trifluoromethylated aryloxy)biphenyls
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概要
- 論文の詳細を見る
Novel bifunctional acyl-acceptant biphenyls bearing trifluoromethylated aroyloxy groups were successfully synthesized in high yields via TfOH-mediated electrophilic aromatic aroylation of fluorobenzene with CF3-bearing aroyl chlorides followed by nucleophilic aromatic substitution with 2,2’-biphenol. Similarly, 2,2’-bis(trifluoromethylphenoxy)biphenyl was synthesized via nucleophilic aromatic substitution of 4-fluorobenzotrifluoride with 2,2’-biphenol. These 2,2’-bis(trifluoromethylated aryloxy)biphenyls show good regioselectivity and successive reactivity in electrophilic aromatic aroylation with p-toluic acid/p-toluoyl chloride according to the structure of the substrate biphenyls, implying their sufficient potential as acyl-accepting precursor molecules for synthesis of aromatic compounds bearing characteristic interfacial properties attributed to CF3 groups.
- 日本油化学会の論文
著者
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Maeyama K
Tokyo Univ. Agriculture And Technol. Tokyo
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Maeyama Katsuya
Department Of Chemistry Tokyo Institute Of Technology
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Katsuya Maeyama
Department Of Organic And Polymer Materials Chemistry Graduate School Of Technology Tokyo University
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NOGUCHI Keiichi
Instrumentation Analysis Center, Tokyo University of Agriculture and Technology
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Yonezawa Noriyuki
Department Of Chemistry Gunma University
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Murakami Yoshihiko
Department Of Chemical Engineering Waseda University
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Okamoto Akiko
Department Of Organic And Polymer Materials Chemistry Tokyo University Of Agriculture And Technology
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Oike Hideaki
Department Of Organic And Polymer Materials Chemistry Tokyo University Of Agriculture & Technolo
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Noguchi Keiichi
Instrumentation Analysis Center Tokyo University Of Agriculture & Technology
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Okamoto Akiko
Department Of Brewing And Fermentation Tokyo University Of Agriculture
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Maeyama Katsuya
Department of Organic & Polymer Materials Chemistry, Tokyo University of Agriculture and Technology
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Oike Hideaki
Department of Organic & Polymer Materials Chemistry, Tokyo University of Agriculture and Technology
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Okamoto Akiko
Department of Allergy and Rheumatology, Graduate School of Medicine, the University of Tokyo
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