Antifungal Activity of Itraconazole and Voriconazole against Clinical Isolates Obtained from Animals with Mycoses

スポンサーリンク

概要

• 論文の詳細を見る

• Animal mycosis, particularly deep mycosis, is one of the most challenging conditions encountered by veterinarians. Pathogens causing mycotic infections in animals include fungi such as Cryptococcus neoformans, Candida spp., and Aspergillus spp. The antifungal drugs used for the treatment of deep mycoses in animals as well as humans are polyenes and azoles. However, the sensitivity of clinical isolates obtained from animals toward these drugs has rarely been assayed. In this study, the antifungal activities of itraconazole and voriconazole against clinical isolates of C. neoformans, Candida spp., and A. fumigatus isolated from animals with mycoses were examined using the broth microdilution method performed according to the guidelines provided by the Clinical and Laboratory Standards Institute. The minimum inhibitory concentrations (MICs) of itraconazole toward the C. neoformans, Candida spp., and A. fumigatus isolates were 0.125 – 1, 0.125 – 2, and 0.25 – 2μg⁄ml, respectively, and those of voriconazole were 0.0625 – 0.5, ≤0.0313 – 0.0625, and 0.0625 – 1μg⁄ml, respectively. The results of the MIC analyses implied that the fungal isolates obtained from infected animals exhibit an equivalent degree of susceptibility to itraconazole and voriconazole, as is observed in the case of isolates obtained from humans. The appropriate antifungal therapeutic strategy for the treatment of mycoses in animals must be selected taking into consideration the host immune status and organ function as well as the in vitro sensitivity of the pathogens to antifungal drugs.

• 2009-04-30

著者

• OKABAYASHI Ken

  Department of Veterinary Biochemistry, College of Bioresource Sciences, Nihon University

• IMAJI Mashio

  Department of Pathobiology, College of Bioresource Sciences, Nihon University

• OSUMI Takafumi

  Department of Pathobiology, College of Bioresource Sciences, Nihon University

• MURAKAMI Yoshihiko

  Department of Pathobiology, College of Bioresource Sciences, Nihon University

• MARUYAMA Haruhiko

  Department of Pathobiology, College of Bioresource Sciences, Nihon University

• KANO Rui

  Department of Pathobiology, College of Bioresource Sciences, Nihon University

• HASEGAWA Atsuhiko

  Department of Pathobiology, College of Bioresource Sciences, Nihon University

• WATANABE Toshi

  Department of Veterinary Biochemistry, College of Bioresource Sciences, Nihon University

• Watari Toshihiro

  Department Of Veterinary Biochemistry College Of Bioresource Sciences Nihon University

• Imaji Mashio

  Department Of Pathobiology College Of Bioresource Sciences Nihon University

• Osumi Takafumi

  Department Of Pathobiology College Of Bioresource Sciences Nihon University

• Kano Rui

  Department Of Pathobiology Nihon University School Of Veterinary Medicine

• Hasegawa Atsuhiko

  Teikyo Univ. Inst. Medical Mycology Tokyo

• Hasegawa Atsuhiko

  Department Of Immunotherapeutics Tokyo Medical And Dental University Graduate School

• Watari Toshihiro

  Laboratory Comprehensive Veterinary Clinical Studies Nihon University School Of Veterinary Medicine

• Watari Toshihiro

  Department Of Veterinary Internal Medicine Faculty Of Agriculture The University Of Tokyo

• Murakami Yoshihiko

  Department Of Pathobiology College Of Bioresource Sciences Nihon University

• Murakami Yoshihiko

  Department Of Chemical Engineering Waseda University

• Okabayashi Ken

  Department Of Veterinary Biochemistry College Of Bioresource Sciences Nihon University

• Maruyama Haruhiko

  Department Of Bioscience Department Of Cardiovascular Surgery

• Kano Rui

  Department of Pathobiology, Nihon University School of Veterinary Medicine

• Okabayashi Ken

  Department of Biology, Faculty of Science, Kobe University

関連論文

• Antifungal Activity of Itraconazole and Voriconazole against Clinical Isolates Obtained from Animals with Mycoses
• Sleep disorder in Rett syndrome and melatonin treatment
• Cerebral oxygenation and hemodynamics during hyperventilation and sleep in patients with Rett syndrome
• Balo's concentric sclerosis in a 4-year-old Japanese infant
• Ocular Granulomatous Meningoencephalomyelitis in a Dog : Magnetic Resonance Images and Clinical Findings(Internal Medicine)
• Molecular epidemiology of Arthroderma benhamiae, an emerging pathogen of dermatophytoses in Japan, by polymorphisms of the non-transcribed spacer region of the ribosomal DNA
• A Case of Recovery from Canine Destructive Cholangitis in a Miniature Dachshund
• Fulminant Eosinophilic Myocarditis Associated With Visceral Larva Migrans Caused by Toxocara Canis Infection
• Small Interfering RNA (siRNA) against the Bcl-2 Gene Increases Apoptosis in a Canine Melanoma Cell Line
• 26S rDNA-Based Phylogenetic Investigation of Japanese Cattle-Associated Prototheca zopfii Isolates
• Reticulated Platelet Levels in Whole Blood and Platelet-Rich Plasma of Dogs with Various Platelet Counts Measured by Flow Cytometry(Clinical Pathology)
• Detection of Sporothrix schenckii chitin synthase 1 (CHS1) gene in biopsy specimens from human patients with sporotrichosis
• Candida albicans induced interleukin 8 production by human keratinocytes
• Bone Marrow Colony-Forming Unit Assay in Cats With Naturally Occurring Myelodysplastic Syndromes
• Cluster Analysis of Human and Animal Pathogenic Microsporum Species and Their Teleomorphic States, Arthroderma Species, Based on the DNA Sequences of Nuclear Ribosomal Internal Transcribed Spacer 1
• Detection of Microsporum canis in the Skin Scrapings and Hairs of Dogs with Dermatophytosis Based on Sequences of the Chitin Synthase 1 Gene
• Characterization of the Cyclophilin of Trichophyton mentagrophytes
• Chitin Synthase 2 Gene Sequence of Malassezia Species
• The First Isolation of Arthroderma benhamiae in Japan
• The First Isolation of Nocardia veterana from a Human Mycetoma
• First Isolation of Stephanoascus ciferrii from a Cat
• Application of Polymerase Chain Reaction to Analysis of Antigen Receptor Rearrangements to Support Endoscopic Diagnosis of Canine Alimentary Lymphoma
• Enhanced UV♀1 tumor growth in CBF1 mice infected with Schistosoma mansoni due to modulation of Th1-like responses
• En Block Resection of Large Hepatocellular Carcinoma Involving the Caudal Vena Cava in a Dog
• Intraepithelial infiltration of eosinophils and their contribution to the elimination of adult intestinal nematode, Strongyloides venezuelensis in mice
• Evaluation of the anthelmintic effects of artesunate against experimental Schistosoma mansoni infection in mice using different treatment protocols
• cDNA Sequencing and Expression of Rat Mast Cell Tryptase^1
• Impaired Tax-specific T-cell responses with insufficient control of HTLV-1 in a subgroup of individuals at asymptomatic and smoldering stages
• Research on calpain of Schistosoma japonicum as a vaccine candidate
• Adult worms of the rodent intestinal nematode, Strongyloides venezuelensis, successfully invatde chick intestinal mucosa
• Cloning and molecuar characterization of calpain, a calcium-activated neutral proteinase, from different strains of Schistoma japonicum
• Immune responses ageinst protozoal and nematodal infection in mice with underlyng Schistosoma mansoni infection
• Synthesis and Characterization of a Temperature-responsive Amphiphilic Block Copolymer Containing a Liquid Crystalline Unit
• Protective Effect of Vaccination with Toxoplasma Lysate Antigen and CpG as an Adjuvant against Toxoplasma gondii in Susceptible C57BL/6 Mice
• Recombinant Vaccinia DIs Expressing Simian Immunodeficiency Virus Gag and Pol in Mammalian Cells Induces Efficient Cellular Immunity as a Safe Immunodeficiency Virus Vaccine Candidate
• Expression of Inter-α-Trypsin Inhibitor Light Chain (Bikunin) in Human Pancreas
• Clinical Features and Outcomes of Eosinophilic Myocarditis Patients Treated with Prednisolone at a Single Institution Over a 27-Year Period
• INFLUENCES OF ALKALINE IONIZED WATER ON MILK ELECTROLYTE CONCENTRATIONS IN MATERNAL RATS
• HISTOPATHOLOGICAL INFLUENCE OF ALKALINE IONIZED WATER ON MYOCARDIAL MUSCLE OF MOTHER RATS
• Poly(Ethylene Glycol)-α-Chymotrypsin Complex Catalytically Active in Anhydrous Isooctane
• Mathematical Approach to Thermolysin-Catalyzed Synthesis of Aspartame Precursor
• ネコの細網内皮症における腫瘍細胞の酵素化学的ならびに免疫学的性状(短報)〔英文〕
• ネコ伝染性腹膜炎ウイルス分離株の性状分析(短報)〔英文〕
• Experimental Infection of Bovine Mammary Gland with Prototheca zopfii Genotype 1
• Small Interfering RNA (siRNA) against the Survivin Gene Increases Apoptosis in a Canine Melanoma Cell Line
• Extraction and Stripping of Copper(I) as a Neocuproine Complex in a Surfactant System and Determination of Copper in Steel
• Case of tinea capitis caused by Trichophyton mentagrophytes (molecular type Arthroderma benhamiae) : Prevalence of a new zoonotic fungal infection in Japan
• Microbiological and Cytological Analysis of Guttural Pouch Lavages Obtained from Apparently Healthy Thoroughbreds
• Induction of IL-10- and IFN-γ-producing T-cell responses by autoreactive T-cells expressing human T-cell leukemia virus type I Tax
• A case report of pleural sparganosis
• Fine binding Specificities to Ascaris suum and Ascaris lumbricoides antigens of the sera from patients of probable visceral larva migrans due to Ascaris suum
• The First Case of Feline Prototheca wickerhamii Infection in Japan
• Clinical study of childhood acute disseminated encephalomyelitis, multiple sclerosis, and acute transverse myelitis in Fukuoka Prefecture, Japan
• In Vitro Algaecide Effect of Disinfectants on Prototheca zopfii Genotypes 1 and 2
• INFLUENCES OF ALKALINE IONIZED WATER ON MILK YIELD, BODY WEIGHT OF OFFSPRING AND PERINATAL DAM IN RATS
• Serotypes and Virulence Factors of Escherichia coli Strains Isolated from Dogs and Cats
• Treatment of Canine Otitis Externa Using Video Otoscopy
• Chloroplast Development in the Chloroplast Ribosome Deficient Mutant (y-1 ac-20) of Chlamydomonas reinhardtii
• EFFECT OF ALKALINE IONIZED WATER ON REPRODUCTION IN GESTATIONAL AND LACTATIONAL RATS
• INFLUENCE OF ALKALINE IONIZED WATER ON RAT ERYTHROCYTE HEXOKINASE ACTIVITY AND MYOCARDIUM
• Synthesis of Novel Trifluoromethyl-bearing Bifunctional Acyl-acceptant Arenes: 2,2’-Bis(trifluoromethylated aryloxy)biphenyls
• Fuchs' Heterochromic Iridocyclitis Associated with Ocular Toxocariasis
• Rapid identification of Prototheca zopfii by nested polymerase chain reaction based on the nuclear small subunit ribosomal DNA
• Double control systems for human T-cell leukemia virus type 1 by innate and acquired immunity
• Zoonotic filariasis caused by Onchocerca dewittei japonica in a resident of Hiroshima Prefecture, Honshu, Japan
• Malignant Transformation of T-cell Large Granular Lymphocyte Leukemia in a Dog
• New Method for Analysis of Enzymatic Reaction : Thermolysin-Catalyzed Synthesis of Aspartame Precursor
• Clinical Features and Rapid Plasma Reagin Antibody Titers in Spontaneous and Experimental Rabbit Syphilis
• Molecular typing and in-vitro activity of azoles against clinical isolates of Aspergillus fumigatus and A. niger in Japan
• Continuous Enzymatic Synthesis of Aspartame Precursor at Low pH Using an Extractive Reaction
• Effects of Indomethacin and Hyperventilation on Cerebral Hemodynamics and Oxygenation in Newborn Piglets
• Two Cases of Feline Orbital Aspergillosis due to Aspergillus udagawae and A. viridinutans
• Three Minimally Invasive Methods of Measuring of Portal Vein Pressure in Healthy Dogs
• Evaluation of Transcervical Insemination Using Frozen Semen by Flexible Endoscope in Dogs
• Reduced production of polymeric immunoglobulin receptor in murine dextran sodium sulfate-induced colitis
• In Vitro Activities of Antifungal Agents against Clinical Isolates of Dermatophytes from Animals
• A Case of Feline Sporotrichosis
• Effects of [6]-Gingerol on Dedifferentiation of Salivary Acinar Cells
• Genotyping of Malassezia pachydermatis Isolates from Canine Healthy Skin and Lesional Skin of Atopic Dermatitis in Japan, Korea and Taiwan
• Successful Resolution of Esophageal Granulomas in a Dog Infected with Spirocerca lupi
• Echinostoma hortense Infection with Enteritis Diagnosed by Upper Gastrointestinal Endoscopy in a Dog
• Decreased Apoptotic Polymorphonuclear Leukocyte Rate in Dogs with Pyometra
• Effects of DDAVP Administrated Subcutaneously in Dogs with Aspirin-induced Platelet Dysfunction and Hemostatic Impairment due to Chronic Liver Diseases.
• In Vitro Susceptibility of Malassezia pachydermatis Isolates from Canine Skin with Atopic Dermatitis to Ketoconazole and Itraconazole in East Asia
• Bronchoalveolar Lavage Fluid and Serum Canine Surfactant Protein A Concentrations in Dogs with Chronic Cough by Bronchial and Interstitial Lung Diseases
• Distribution of Inclusion Bodies in Tissues from 100 Dogs Infected with Canine Distemper Virus
• A Hematological Study on Thirteen Cats with Myelodysplastic Syndrome.
• Chronic Myelomonocytic Leukemia in a Cat.
• Degradation of Myocardiac Myosin and Creatine Kinase in Rats Given Alkaline Ionized Water.
• Changes of Cerebral Hemodynamics and Oxygenation in Unstable Septic Newborns during Exchange Transfusion.
• Retrospective Serological Analysis of Spontaneous CDV Infection in 192 Dogs

もっと見る 閉じる

スポンサーリンク