Effects of DDAVP Administrated Subcutaneously in Dogs with Aspirin-induced Platelet Dysfunction and Hemostatic Impairment due to Chronic Liver Diseases.
スポンサーリンク
概要
- 論文の詳細を見る
To evaluate the hemostatic effects of desmopressin (DDAVP) in dogs with aspirin-induced platelet dysfunction and hemostatic impairment in chronic liver diseases, 3 μg/kg DDAVP was administrated subcutaneously. In aspirin-induced platelet dysfunction dogs (n=5), prolonged BMBT (buccal mucosal bleeding time) was shortened significantly after DDAVP injection (2.2 ± 1.2 min, P<0.05). In dogs with chronic liver diseases (n=4), activated partial thromboplastin time (APTT) tended to shorten by 0.9 to 3.0 sec, and prolonged BMBT was shortened in two cases for 4.2 and 1.7 min after DDAVP injection. Therefore, the present results indicated that DDAVP shortened the prolonged BMBT in dogs with aspirin-induced platelet dysfunction and chronic liver disease. DDAVP might be helpful in hemostasis under invasive procedures such as biopsy or surgery for dogs with hemostatic impairment.
- 公益社団法人 日本獣医学会の論文
著者
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Watari Toshihiro
Laboratory Comprehensive Veterinary Clinical Studies Nihon University School Of Veterinary Medicine
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KOIE Hiroshi
Laboratory of Comprehensive Veterinary Clinical Studies
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Yamaya Yoshiki
Laboratory Of Veteriary Surgery College Of Bioresourse Sciences Nihon University
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Hasegawa Atsuhiko
Laboratory Of Veterinary Pathobiology Nihon University School Of Veterinary Medicine
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Takeuchi Akira
Laboratory Of Biochemistry Faculty Of Agriculture Nagoya University
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KOIE Hiroshi
Laboratory of Comprehensive Veterinary Clinical Studies, Department of Veterinary Medicine, Nihon University
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WATARI Toshihiro
Laboratory of Comprehensive Veterinary Clinical Studies, Department of Veterinary Medicine, Nihon University
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SAKAI Manabu
Laboratory of Comprehensive Veterinary Clinical Studies, Department of Veterinary Medicine, Nihon University
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MIURA Teruhisa
Laboratory of Comprehensive Veterinary Clinical Studies, Department of Veterinary Medicine, Nihon University
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MARUYAMA Haruhiko
Laboratory of Comprehensive Veterinary Clinical Studies, Department of Veterinary Medicine, Nihon University
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YAMAYA Yoshiki
Laboratory of Comprehensive Veterinary Clinical Studies, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University
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YAMAYA Yoshiki
Laboratory of Comprehensive Veterinary Clinical Studies, Department of Veterinary Medicine, Nihon University
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HASEGAWA Atsuhiko
Laboratory of Pathobiology, Department of Veterinary Medicine, Nihon University
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SAKAI Manabu
Laboratory of Comprehensive Veterinary Clinical Studies, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University
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