Clinical Significance of Circulating Vascular Endothelial Growth Factor in Dogs with Mammary Gland Tumors

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概要

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• Increase in circulating vascular endothelial growth factor (VEGF) is suggested as a prognostic indicator in human patients with malignant tumors. The purpose of this study was to evaluate the clinical significance of circulating VEGF in dogs with mammary gland tumors (MGT). Both plasma and serum VEGF were significantly higher in dogs with MGT when compared with those in the healthy dogs. In dogs with MGT, the plasma and serum VEGF of the malignant group increased significantly compared with those of the benign group. Additionally, there was a significant difference between the plasma and serum VEGF in the groups with postoperative metastasis and no metastasis. Circulating VEGF is expected to be clinically available for the determination of prognosis in canine MGT.

• 公益社団法人 日本獣医学会の論文

著者

• TANAKA Shigeo

  Laboratory of Veterinary Surgery, Department of Veterinary Medicine, College of Bioresource Science,

• Hasegawa Atsuhiko

  Laboratory Of Veterinary Pathobiology Nihon University School Of Veterinary Medicine

• TSUMAGARI Shigehisa

  Laboratory of Theriogenology, College of Bioresource Sciences, Nihon University

• KATO Yuka

  Laboratory of Veterinary Surgery, College of Bioresource Sciences, Nihon University

• ASANO Kazushi

  Laboratories of Veterinary Surgery, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University

• TESHIMA Kenji

  Laboratories of Veterinary Surgery, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University

• EDAMURA Kazuya

  Laboratories of Veterinary Surgery, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University

• KUTARA Kenji

  Laboratories of Veterinary Surgery, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University

• MOGI Toshiaki

  Laboratory of Veterinary Surgery, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University

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