Gene Expression of Growth Factors and Growth Factor Receptors for Potential Targeted Therapy of Canine Hepatocellular Carcinoma
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概要
- 論文の詳細を見る
The purpose of this study was to evaluate the gene expression of growth factors and growth factor receptors of primary hepatic masses, including hepatocellular carcinoma (HCC) and nodular hyperplasia (NH), in dogs. Quantitative real-time reverse transcriptase-polymerase chain reaction was performed to measure the expression of 18 genes in 18 HCCs, 10 NHs, 11 surrounding non-cancerous liver tissues and 4 healthy control liver tissues. Platelet-derived growth factor-B (PDGF-B), transforming growth factor-α, epidermal growth factor receptor, epidermal growth factor and hepatocyte growth factor were found to be differentially expressed in HCC compared with NH and the surrounding non-cancerous and healthy control liver tissues. PDGF-B is suggested to have the potential to become a valuable ancillary target for the treatment of canine HCC.
- 公益社団法人 日本獣医学会の論文
著者
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KAGAWA Yumiko
North Lab
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Asano Kazushi
Laboratory Of Veterinary Surgery Department Of Veterinary Clinical Sciences Graduate School Of Veter
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Edamura Kazuya
Laboratory Of Veterinary Emergency Medicine Graduate School Of Agricultural And Life Sciences The Un
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TESHIMA Kenji
Laboratory of Veterinary Surgery, Department of Veterinary Medicine, College of Bioresource Sciences
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KUTARA Kenji
Laboratory of Veterinary Surgery, Department of Veterinary Medicine, College of Bioresource Sciences
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WATARI Toshihiro
Comprehensive Veterinary Clinical Studies, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University
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IIDA Gentoku
Laboratories of Veterinary Surgery, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University
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ISHIGAKI Kumiko
Laboratories of Veterinary Surgery, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University
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SAKAI Manabu
Veterinary Internal Medicine, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University
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SEKI Mamiko
Comprehensive Veterinary Clinical Studies, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University
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YOSHIDA Orie
Laboratories of Veterinary Surgery, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University
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ASANO Kazushi
Laboratories of Veterinary Surgery, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University
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TESHIMA Kenji
Laboratories of Veterinary Surgery, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University
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