In Vitro Susceptibility of Malassezia pachydermatis Isolates from Canine Skin with Atopic Dermatitis to Ketoconazole and Itraconazole in East Asia
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概要
- 論文の詳細を見る
Topical or oral azole antifungals are commonly used in canine atopic dermatitis (AD) as the lipophilic yeast Malassezia pachydermatis exacerbates canine AD. To examine whether canine AD lesions harbor azole-resistant M. pachydermatis isolates in East Asia, we investigated the in vitro susceptibility of M. pachydermatis isolates to ketoconazole (KTZ) and itraconazole (ITZ) obtained from AD lesions of canines in Japan, Korea and Taiwan. The minimum inhibitory concentrations (MICs) of KTZ and ITZ were measured by the E-test using Sabouraud's dextrose agar with 0.5% Tween 40. The MICs of KTZ and ITZ for isolates from canines with AD were significantly higher from the MICs for isolates from healthy canines. Our findings suggested that the clinical isolates from canine AD skin lesions were less susceptible to azoles than those from normal canine skin in East Asia.
- 公益社団法人 日本獣医学会の論文
著者
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NAGATA Masahiko
ASC Dermatology Service
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Kamata Hiroshi
Department Of Pathobiology Nihon University School Of Veterinary Medicine
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Kano Rui
Department Of Pathobiology Nihon University School Of Veterinary Medicine
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Hasegawa Atsuhiko
Teikyo Univ. Inst. Medical Mycology Tokyo
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KOIKE Anna
Department of Pathobiology, Nihon University School of Veterinary Medicine, 1866 Kameino, Fujisawa, Kanagawa 252–0880, Japan
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CHEN Charles
Asian Veterinary Specialist Referral Center, 1st Floor, No. 109, Section 4, XinYi Road, Taipei 106, Taiwan
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HWANG Cheol-Yong
Department of Internal Medicine (Dermatology), College of Veterinary Medicine, Seoul National University
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WATANABE Shion
Department of Pathobiology, Nihon University School of Veterinary Medicine
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KOIKE Anna
Department of Pathobiology, Nihon University School of Veterinary Medicine
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CHEN Charles
Asian Veterinary Specialist Referral Center
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