Two Cases of Feline Orbital Aspergillosis due to Aspergillus udagawae and A. viridinutans

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概要

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• Aspergillus udagawae and A. viridinutans are members of the section Fumigati; both cause invasive aspergillosis in humans. These two Aspergillus species are discriminated from A. fumigatus by molecular methods. Herein, we report two cases of feline orbital aspergillosis, one caused by A. udagawae and the other by A. viridinutans. To our knowledge, Case 1 represents the first reported case of treatment of A. udagawae with a high dosage of itraconazole, and Case 2 represents the first reported case of A. viridinutans infection associated with sarcoma. Identification of the etiologic agents of these cases was confirmed by comparative analyses of the sequences of β-tubulin-encoding genes. With the spread of non-fumigatus aspergillosis, increasing emphasis should be placed on molecular identification of the infecting Aspergillus species and the use of in vitro drug susceptibility tests to ensure the selection of appropriate antibiotics.

著者

• Fujino Yasuhito

  Department Of Veterinary Internal Medicine Graduate School Of Agricultural And Life Sciences The Uni

• Kano Rui

  Department Of Pathobiology Nihon University School Of Veterinary Medicine

• Yanai Tokuma

  Department Of Veterinary Pathology Faculty Of Agriculture Gifu University

• Hasegawa Atsuhiko

  Teikyo Univ. Inst. Medical Mycology Tokyo

• Tsujimoto Hajime

  Department Of Internal Medicine And Veterinary Hospital Division Of Veterinary Medicine The Universi

• Mori Takashi

  Laboratory Of Food Quality Design And Development Graduate School Of Agriculture Kyoto University

• Sakai Hiroki

  Department Of Food Science Niigata University Of Pharmacy And Applied Life Sciences

• HASEGAWA Atsuhiko

  Teikyo University Institute of Medical Mycology, 539 Otsuka, Hachioji, Tokyo 192–0395, Japan

• SHIBAHASHI Ayami

  Laboratory of Veterinary Clinical Oncology, Department of Veterinary Medicine, Gifu University, 1–1 Yanagido, Gifu 501–1193, Japan

• YANAI Tokuma

  Department of Pathogenetic Veterinary Sciences, United Graduate School of Veterinary Sciences, Gifu University, 1–1 Yanagido, Gifu 501–1193, Japan

• YANAI Tokuma

  Department of Veterinary Pathology, Faculty of Applied Biological Science, Gifu University, 1–1 Yanagido, Gifu 501–1193, Japan

• KANO Rui

  Department of Pathobiology, Nihon University School of Veterinary Medicine, 1866 Kameino, Fujisawa, Kanagawa 252–0880, Japan

• FUJINO Yasuhito

  Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1–1–1 Yayoi, Bunkyo-ku, Tokyo 113–8657, Japan

• SAKAI Hiroki

  Department of Veterinary Pathology, Faculty of Applied Biological Science, Gifu University, 1–1 Yanagido, Gifu 501–1193, Japan

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