EFFECTS OF ATROPINE SULFATE ON RAT HARDERIAN GLANDS : CORRELATION BETWEEN MORPHOLOGICAL CHANGES AND PORPHYRIN LEVELS
スポンサーリンク
概要
- 論文の詳細を見る
We examined the correlation between histopathological changes and porphyrin levels in the Harderian glands of male rats after treatment with atropine sulfate. After a single administration of atropine sulfate(250 mg/kg/day), the porphyrin levels in the Harderian glands gradually increased, beginning from 2 hr after administration, and at 36 hr reached a maximum level, which was about 7 times higher than that of the control animals. Histopathologically, the Harderian glands showed marked luminal dilatation and a brownish pigment accumulation in the lumina 6 hr after a single dose. Under daily repeated administrations of atropine sulfate(250 mg/kg/day), the highest porphysin levels in the Harderian glands were observed 24 hr after the third dose, and were about 9 times higher than those of the control animals. However, beginning from one week after the initial dose, much lower peak porphyrin levels were observed 6 hr after each dose. The maximum porphyrin levels were only twice as high as those of the control animals, and they returned to the control levels 24 hr after each atropine dose. Histological examinations of the Harderian glands revealed that repeated administrations of atropine sulfate induced the same histopathological changes observed after a single atropine administration, and that no aggravated dilation of the lumina or pigmentation in the lumina appeared after such repeated administrations. The degree and incidence of the histopathological changes observed correlated well with the porphyrin levels. Some animals showed a degeneration of the glandular epithelium after 4 weeks of treatment, and the frequency increased slightly after 13 weeks of treatment. The present study suggests that atropine suppresses the expulsion of secretory materials, including porphyrin, from the glandular lumen of the Harderian glands, and thereafter an excessive accumulation of porphyrin induced luminal dilatation. These changes were gradually reduced by repeated administrations. The degeneration of the glandular epithelium after repeated administration might be a consequence of retention of an excessive accumulation of porphyrin.
- 日本トキシコロジー学会の論文
- 2000-08-17
著者
-
YANAI Tokuma
Department of Veterinary Pathology, Gifu University
-
MASEGI Toshiaki
Department of Veterinary Pathology, Gifu University
-
Tagawa Yoshiaki
Developmental Research Group Central Research Laboratory Sanwa Kagaku Kenkyusho Co. Ltd.
-
IWAI Hisakazu
Developmental Research Group, Central Research Laboratory, Sanwa Kagaku Kenkyusho Co., Ltd.
-
HAYASAKA Ikuo
Kumamoto Primates Research Park, Sanwa Kagaku Kenkyusho Co., Ltd.
-
Hayasaka Ikuo
Kumamoto Primate Park Sanwa Kagaku Kenkyusho
-
Iwai H
Developmental Research Group Central Research Laboratory Sanwa Kagaku Kenkyusho Co. Ltd.
-
Yanai Tokuma
Department Of Veterinary Pathology Gifu University
-
Yanai Tokuma
Department Of Veterinary Pathology Faculty Of Agriculture Gifu University
-
Iwai Hisakazu
Developmental Research Group Central Research Laboratory Sanwa Kagaku Kenkyusho Co. Ltd.
-
Masegi Toshiaki
Department Of Veterinary Pathology Gifu University
-
Masegi Toshiaki
Department Of Veterinary Pathology Faculty Of Agriculture Gifu University
-
Totsuka Yukari
国立がん研究センター研究所 発がんシステム研究分野
-
Masegi Toshiaki
Department Of Gastroenterology And Metabolism Nagoya City University Graduate School Of Medical Scie
-
YANAI Tokuma
Department of Pathogenetic Veterinary Sciences, United Graduate School of Veterinary Sciences, Gifu University, 1–1 Yanagido, Gifu 501–1193, Japan
関連論文
- Retroperitoneal Fibromatosis in a Cynomolgus Monkey (Macaca fascicularis)
- 飼育下のユキヒョウ(Uncia uncia)に感染が認められた犬糸状虫(Dirofilaria immitis)の形態およびミトコンドリアDNA配列(短報)(寄生虫病学)
- Enhancement of esophageal carcinogenesis in acid reflux model rats treated with ascorbic acid and sodium nitrite in combination with or without initiation
- 食塩剥離皮膚標本における基底膜蛋白の局在(短報)
- 抗基底腹抗体を有する犬の円板状紅斑性狼瘍の1例
- Roles of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 expression and β-catenin activation in gastric carcinogenesis in N-methyl-N-nitrosourea-treated K19-C2mE transgenic mice
- Organ-dependent susceptibility of p53 knockout mice to 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)
- Detection of Initiating and Promoting Activity of Aminophenylnorharman with a Five-week In Vivo Initiation Assay
- Gastric Carcinogenesis and Intestinalization Induced by N-methyl-N-nitrosourea in the Senescence-Accelerated Mouse (SAMP3)
- Tongue Carcinogenic Susceptibility of p53 Deficient Mice to Methyl-n-amylnitrosamine
- Lack of a Dose-response Relationship for Carcinogenicity in the Rat Liver with Low Doses of 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline or N-Nitrosodiethylamine
- The Effects of Allyl Alcohol-induced Cell Proliferation for Detection of Initiation Activities of Chemicals in Rat Liver
- The Effects of D-galactosamine- or Carbon Tetrachloride-Induced Regeneration on Induction of Rat Liver Cell Foci in a Model for Detection of Initiation Activities of Chemicals
- Differential Effects of Partial Hepatectomy and Carbon Tetrachloride Administration on Induction of Liver Cell Foci in a Model for Detection of Initiation Activity
- N-Methyl-N-nitrosourea Concentration-dependent, Rather than Total Intake-dependent, Induction of Adenocarcinomas in the Glandular Stomach of BALB/c Mice
- Sparse Distribution of Hepatocyte Growth Factor-producing Cells inside Hepatocellular Foci in Rats Treated with Hepatocarcinogens
- Enhancement of urinary bladder carcinogenesis by combined treatment with benzyl isothiocyanate and N-butyl-N-(4-hydroxybutyl) nitrosamine in rats after initiation
- Lung as a new target in rats of 2-amino-3-methylimidazo[4,5-f]quinoline carcinogenesis : Results of a two-stage model initiated with N-bis(2-hydroxypropyl)nitrosamine
- In vivo Approaches to Study Mechanism of Action of Genotoxic Carcinogens
- ウレタンの大量投与によりヒトプロト型c-Ha-rasトランスジェニック(rasH2)マウスに誘発された肺増殖性病変におけるCyclinD1の過剰発現
- Establishment and characterization of a human colonic mucinous carcinoma cell line with predominant goblet-cell differentiation from liver metastasis
- 犬における肉芽腫性髄膜脳脊髄炎と中枢性悪性組織球症の病理学的比較(病理学)
- 犬の壊死性髄膜脳炎と肉芽腫性髄膜脳脊髄炎の病理学的比較検討(病理学)
- Enhancing effects of carbon tetrachloride on in vivo mutagenicity in the liver of mice fed 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx)
- Effects of co-treatment of dextran sulfate sodium and MeIQx on genotoxicity and possible carcinogenicity in the colon of p53-deficient mice
- Existence of a no effect level for MeIQx hepatocarcinogenicity on a background of thioacetamide-induced liver damage in rats
- EFFECTS OF ATROPINE SULFATE ON RAT HARDERIAN GLANDS : CORRELATION BETWEEN MORPHOLOGICAL CHANGES AND PORPHYRIN LEVELS
- 203 PORPHYRIN CONTENT IN THE HARDERIAN GLAND OF ATROPINE-TREATED RATS
- Comparative Study on Toxicokinetics of Bisphenol A in F344 Rats, Monkeys (Macaca fascicularis), and Chimpanzees (Pan troglodytes)
- Analysis of cDNA Coding MHC Class II β Chain of The Chimpanzee (Pan troglodytes)
- 新型ウマヘルペスウイルス9型(ガゼルヘルペスウイルス1型)のウマに対する病原性(短報)
- Induction of DNA-adducts and increase of 8-hydroxy-2-deoxyguanosine, but no development of preneoplastic lesions in offspring liver with transplacental and trans-breast milk exposure to 2-amino-3, 8-dimethylimidazo [4, 5-f] quinoxaline (MeIQx) in rats
- IMMUNOHISTOCHEMICAL STUDIES OF TSH-PRODUCING CELLS IN THE PITUITARY AND EXPRESSION OF GROWTH FACTORS IN THYROIDAL PROLIF-ERATIVE LESIONS IN RATS TREATED WITH THIOUREA AND EXCESS VITAMIN A
- Point Mutations of the c-H-ras Gene in Spontaneous Pulmonary Tumors of Transgenic Mice Carrying the Human c-H-ras Gene
- 後躯不全麻痺を示したフェレットの椎骨に発生した線維肉腫の1例
- SPECIES DIFFERENCE IN SUSCEPTIBILITY TO PHORBOL MYRISTATE ACETATE-INDUCED LEUKOPENIA AND LUNG INJURY : RAT VS. DOG
- Hepatozoon ursi n. sp. (Apicomplexa : Hepatozoidae) in Japanese black bear (Ursus thibetanus japonicus)
- Evaluation of Cell Proliferation in Canine Tumors by the Bromodeoxyuridine Labeling Method, Immunostaining of Ki-67 Antigen and Proliferating Cell Nuclear Antigen
- Immunohistochemical Demonstration of S-phase Cells in Canine and Feline Spontaneous Tumors by Anti-bromodeoxyuridine Monoclonal Antibody
- イヌのエプーリスに関する臨床病理学的研究
- A11 Hepatic foamy cell in Fischer 344 rats : Its age-related morphological properties.
- LARGE AMOUNT OF VITAMIN A HAS NO MAJOR EFFECTS ON THYROIDAL HORMONE SYNTHESIS IN TWO-STAGE RAT THYROID CARCINOGENESIS MODEL USING N-BIS(2-HYDROXYPROPYL)NITROSAMINE AND THIOUREA
- Development of the Hand and Wrist Bones in Chimpanzees
- A comparative pathological study on granulomatous meningoencephalomyelitis and central malignant histiocytosis in dogs
- Development of the sexual skin with pubertal maturation in female chimpanzees
- Proliferative Potential of a Spinal Nephroblastoma in a Young Dog
- Molecular Genetic and Pathogenic Characterization of Psittacid Herpesvirus Type 1 Isolated from a Captive Galah (Eolophus roseicapillus) in Japan
- Oxidative DNA damage and reporter gene mutation in the livers of gpt delta rats given non-genotoxic hepatocarcinogens with cytochrome P450-inducible potency
- Low-dose carcinogenicity of 2-amino-3-methylimidazo[4,5-f]quinoline in rats : Evidence for the existence of no-effect levels and a mechanism involving p21^
- Aberrant Expression of Cyclin D1 in Pulmonary Proliferative Lesions Induced by High Doses of Urethane in Transgenic Mice Carrying the Human Prototype c-H-ras Gene
- Rhabdomyosarcoma in a Ferret (Mustela putorius furo)
- Two Cases of Feline Orbital Aspergillosis due to Aspergillus udagawae and A. viridinutans
- Uterine Carcinosarcoma in a 2-year-old Female Wistar Hannover GALAS Rat
- Proliferative Potential of a Spinal Nephroblastoma in a Young Dog
- Effect of Butylated Hydroxytoluene on Cell Population in Rat Hepatocytes
- Coenurus cerebralis Cysts in the Left Lateral Cerebral Ventricle of a Ewe
- Pathogenicity of a New Neurotropic Equine Herpesvirus 9(Gazelle Herpesvirus 1) in Horses.
- Histopathological Characteristics of Spindle-cell Proliferative Disease in Broiler Chickens and Its Experimental Reproduction in Specific Pathogen-Free Chickens