Notch2 Transduction by Feline Leukemia Virus in a Naturally Infected Cat
スポンサーリンク
概要
- 論文の詳細を見る
Feline leukemia virus (FeLV) induces neoplastic and non-neoplastic diseases in cats. The transduction of cellular genes by FeLV is sometimes observed and associated with neoplastic diseases including lymphoma and sarcoma. Here, we report the first natural case of feline Notch2 transduction by FeLV in an infected cat with multicentric lymphoma and hypercalcemia. We cloned recombinant FeLVs harboring Notch2 in the env gene. Notch2 was able to activate expression of reporter gene, similar to what was previously reported in cats with experimental FeLV-induced thymic lymphoma. Our findings suggest that the transduction of Notch2 strongly correlates with FeLV-induced lymphoma.
- 公益社団法人 日本獣医学会の論文
著者
-
NISHIGAKI Kazuo
Laboratory of Molecular Immunology and Infectious Disease, Faculty of Agriculture, Yamaguchi Univers
-
Hisasue Masaharu
Laboratory Of Internal Medicine Ii School Of Veterinary Medicine Azabu University
-
Tsujimoto Hajime
Department Of Internal Medicine And Veterinary Hospital Division Of Veterinary Medicine The Universi
-
WATANABE Shinya
Laboratory of Veterinary Pharmacology, Kitasato University, Towada, Aomori 034–8628, Japan
-
BABA Takuya
Laboratory of Molecular Immunology and Infectious Disease, Joint Faculty of Veterinary Medicine, Yamaguchi University
-
HIRATSUKA Takahiro
Laboratory of Molecular Immunology and Infectious Disease, Joint Faculty of Veterinary Medicine, Yamaguchi University
-
ITO Jumpei
Laboratory of Molecular Immunology and Infectious Disease, Joint Faculty of Veterinary Medicine, Yamaguchi University
-
KUSE Kyohei
Laboratory of Molecular Immunology and Infectious Disease, Joint Faculty of Veterinary Medicine, Yamaguchi University
-
OCHI Haruyo
Laboratory of Molecular Immunology and Infectious Disease, Joint Faculty of Veterinary Medicine, Yamaguchi University
-
ANAI Yukari
Laboratory of Molecular Immunology and Infectious Disease, Joint Faculty of Veterinary Medicine, Yamaguchi University
関連論文
- Potential Immunological Adjuvant of K-Type CpG-Oligodeoxynucleotides Enhanced the Cell Proliferation and IL-6 mRNA Transcription in Canine B cells
- An Updated Nation-Wide Epidemiological Survey of Feline Immunodeficiency Virus (FIV) Infection in Japan
- Preparation of Positive Control Platelets for Detection of Canine Platelet Surface-Associated IgG, IgM and Complement (C3) by Flow Cytometry
- Characterization of Monocyte-Derived Dendritic Cells from Cats Infected with Feline Immunodeficiency Virus
- Quantitative Analysis of mRNA for 10 Different Drug Resistance Factors in Dogs with Lymphoma
- Cultivation and Characterization of Canine Skin-Derived Mast Cells
- A Rapid and Simple Method to Obtain Canine Peripheral Blood-Derived Macrophages
- Anti-Tumor Effect of Adenoviral Vector-Mediated p53 Gene Transfer on the Growth of Canine Osteosarcoma Xenografts in Nude Mice
- A Case of Recovery from Canine Destructive Cholangitis in a Miniature Dachshund
- Reticulated Platelet Levels in Whole Blood and Platelet-Rich Plasma of Dogs with Various Platelet Counts Measured by Flow Cytometry(Clinical Pathology)
- Bone Marrow Colony-Forming Unit Assay in Cats With Naturally Occurring Myelodysplastic Syndromes
- Characterization of the Cyclophilin of Trichophyton mentagrophytes
- The First Isolation of Arthroderma benhamiae in Japan
- A Retrospective Study in 21 Shiba Dogs with Chronic Enteropathy
- Long Term Survival of Primary Skeletal Muscle Lymphoma in a Miniature Dachshund
- Evaluation of Prognostic Factors and Establishment of a Prognostic Scoring System for Canine Primary Immune-Mediated Hemolytic Anemia
- Quantitative Analysis of mRNA Transcripts of Hox, SHH, PTCH, Wnt, and Fzd Genes in Canine Hematopoietic Progenitor Cells and Various in vitro Colonies Differentiated from the Cells(Internal Medicine)
- Inhibitory Effect of Newly Developed CXC-Chemokine Receptor 4 Antagonists on the Infection with Feline Immunodeficiency Virus(Virology)
- Investigation of Various Methods for the Cryopreservation of Canine Bone Marrow-Derived CD34^+ Cells(Internal Medicine)
- Hypereosinophilic Syndrome in Two Cats(Clinical Pathology)
- Inhibition of the Replication of Feline Immunodeficiency Virus by Lentiviral Vector-Mediated RNA Interference in Feline Cell Lines(Clinical Pathology)
- Verification of Measurement of the Feline Serum Amyloid A (SAA) Concentration by Human SAA Turbidimetric Immunoassay and Its Clinical Application(Clinical Pathology)
- Sensitivity for the Detection of a Clonally Rearranged Antigen Receptor Gene in Endoscopically Obtained Biopsy Specimens from Canine Alimentary Lymphoma
- Immunological Findings in 3 Dogs Clinically Diagnosed with Allergic Rhinitis
- Real-Time Ultrasonographic Evaluation of Canine Gastric Motility in the Postprandial State
- Disseminated Histiocytic Sarcoma with Excessive Hemophagocytosis in a Cat
- Sister Chromatid Exchange (SCE) Frequency in Human and Simian Lymphoid Cell Lines Infected with Simian Retroviruses Closely Related to Human T-cell Leukemia Virus Type-1
- A Case of Atypical Canine Lymphoma with Oral Mass and Multiple Osteolysis
- Neutropenia Associated with Osteomyelitis due to Hepatozoon canis Infection in a Dog
- Comparison between Immunohistochemistry and Genetic Clonality Analysis for Cellular Lineage Determination in Feline Lymphomas
- An Epidemiological Survey of Feline Hemoplasma Infection in Japan
- Clinical Efficacy of a Novel Elimination Diet Composed of a Mixture of Amino Acids and Potatoes in Dogs with Non-Seasonal Pruritic Dermatitis
- Aggregability and Post-Transfusion Survival of Canine Platelets in Stored Whole Blood
- Prokinetic Effect of the 5-HT4R Agonist Mosapride on Canine Gastric Motility
- Plasma High-Mobility Group Box 1 (HMGB1) in Dogs with Various Diseases: Comparison with C-Reactive Protein
- Specificity of an enzyme-linked immunosorbent assay for dog IgE antibody to Japanese cedar (Cryptomeria japonica) pollen
- A Case of Canine Multiple Inflammatory Colorectal Polyps Treated by Endoscopic Polypectomy and Argon Plasma Coagulation
- Identification of Bovine Serum Albumin as an IgE-Reactive Beef Component in a Dog with Food Hypersensitivity against Beef
- A Dog with Myelodysplastic Syndrome: Chronic Myelomonocytic Leukemia
- Prevalence of Canine Distemper Virus, Feline Immunodeficiency Virus and Feline Leukemia Virus in Captive African Lions (Panthera leo) in Japan
- Two Cases of Feline Orbital Aspergillosis due to Aspergillus udagawae and A. viridinutans
- Effect of Mosapride on Prednisolone-Induced Gastric Mucosal Injury and Gastric-Emptying Disorder in Dog
- Measurement for Canine IgE Using Canine Recombinant High Affinity IgE Receptor α Chain (FcεRIα)
- A Retrospective Study of Inflammatory Colorectal Polyps in Miniature Dachshunds
- Polypoid Adenomas Secondary to Inflammatory Colorectal Polyps in 2 Miniature Dachshunds
- Lymphocyte Blastogenic Responses to Food Antigens in Cats Showing Clinical Symptoms of Food Hypersensitivity
- Intestinal T-Cell Lymphoma with Severe Hypereosinophilic Syndrome in a Cat
- Lymphangiomatosis of the Systemic Skin in an Old Dog
- Analyses on Activation of NF-κB and Effect of Bortezomib in Canine Neoplastic Lymphoid Cell Lines
- Simultaneous Inactivation of the p16, p15 and p14 Genes Encoding Cyclin-Dependent Kinase Inhibitors in Canine T-Lymphoid Tumor Cells
- Value of the 13C-Urea Breath Test for Detection of Gastric Helicobacter spp. Infection in Dogs Undergoing Endoscopic Examination
- Accumulation of Xenotransplanted Canine Bone Marrow Cells in NOD/SCID/γcnull Mice with Acute Hepatitis Induced by CCl4
- Development and Evaluation of a Novel In-Clinic Automated Hematology Analyzer, ProCyte Dx, for Canine Erythrocyte Indices, Leukogram, Platelet Counts and Reticulocyte Counts
- Identification of Cell Surface Antigen Expression in Canine Hepatocellular Carcinoma Cell Lines
- Cytomorphological and Immunological Classification of Feline Lymphomas: Clinicopathological Features of 76 Cases
- Inhibitory Effects of Psychotropic Drugs on the Acetylcholine Receptor-Operated Potassium Current (IK.ACh) in Guinea-Pig Atrial Myocytes
- A Retrospective Study on Adverse Reactions to Canine Vaccines in Japan.
- The Regulation of the Expression of ABCG2 Gene through Mitogen-Activated Protein Kinase Pathways in Canine Lymphoid Tumor Cell Lines
- Plasma Transferrin Concentration as a Nutritional Marker in Malnourished Dogs with Nutritional Treatment
- Notch2 Transduction by Feline Leukemia Virus in a Naturally Infected Cat
- Blood Hyaluronic Acid as a Marker for Canine Cirrhosis
- Antigen-Specific Histamine Release in Dogs with Food Hypersensitivity.
- Antigen-specific Enhancements of CD80 mRNA Expression in Experimentally Sensitized Dogs with Japanese Cedar Pollen.