Reduced production of polymeric immunoglobulin receptor in murine dextran sodium sulfate-induced colitis
スポンサーリンク
概要
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Polymeric immunoglobulin receptor (pIgR) plays an intrinsic role in protecting the intestinal tract from invading pathogens. In the present study, we observed a decrease in pIgR in colon lysate from mice with dextran sodium sulfate (DSS) colitis. A decrease in pIgR was detected in both mRNA and protein levels. Histologic examinations revealed marked destruction of intestinal epithelial cells (IECs), and only a small number of regenerating IECs expressed pIgR. These results suggest that the decrease in pIgR was due to the destruction of IECs. Because activation of toll-like receptor 3 slows the progression of DSS colitis, we injected polyriboinosinic: polyribocytidylic acid (poly I:C) intraperitoneally and observed the correlation between pIgR level and severity of DSS colitis. Poly I:C markedly decreased progression of DSS colitis, and pIgR levels significantly recovered. Furthermore, we found that expressions of IFN-γ and TNF-α were higher in DSS colitis. These results indicate that the decrease in pIgR was not compensated for by increased expression of these cytokines. In sum, our findings show that pIgR levels vary according to the severity of DSS colitis and that these changes might be useful as a biomarker of the severity of inflammatory bowel disease. (J Oral Sci 54, 23-32, 2012)
著者
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WATANABE Toshi
Department of Veterinary Biochemistry, College of Bioresource Sciences, Nihon University
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Komiyama Kazuo
Department Of Oral And Maxillofacial Surgery Nihon University School Of Dentistry
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Asano Masatake
Department Of Pathology Nihon University School Of Dentistry
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Okabayashi Ken
Department of Biology, Faculty of Science, Kobe University
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Takiguchi Hatakazu
Division of Oral Health Sciences, Nihon University Graduate School of Dentistry
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Endo Shigeki
Division of Applied Oral Sciences, Nihon University Graduate School of Dentistry
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Omagari Daisuke
Department of Pathology, Nihon University School of Dentistry
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