Vitamin D and periodontal disease
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概要
- 論文の詳細を見る
1,25-Dihydroxyvitamin D<Sub>3</Sub> [1,25(OH)<Sub>2</Sub>D<Sub>3</Sub>; 1,25-dihydroxycholecalciferol or calcitriol] is the active form of vitamin D<Sub>3</Sub>, a lipid-soluble vitamin that plays a role in calcium and bone metabolism. Recently, vitamin D<Sub>3</Sub> has been shown to function in cancer prevention, immunity and cardiovascular regulation. 1,25(OH)<Sub>2</Sub>D<Sub>3</Sub> exhibits physiological and pharmacological effects by activating the vitamin D receptor (VDR), a transcription factor of the nuclear receptor superfamily. 1,25(OH)<Sub>2</Sub>D<Sub>3</Sub> plays a role in maintaining oral health through its effects on bone and mineral metabolism and innate immunity, and several VDR gene polymorphisms have been reported to be associated with periodontal disease. VDR ligands should prove to be useful in the treatment and prevention of periodontal disease. (J Oral Sci 51, 11-20, 2009)
- 日本大学歯学部の論文
著者
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Komiyama Kazuo
Department Of Oral And Maxillofacial Surgery Nihon University School Of Dentistry
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Makishima Makoto
Division of Biochemistry, Department of Biomedical Sciences, Nihon University School of Medicine
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Amano Yusuke
Division of Biochemistry, Department of Biomedical Sciences, Nihon University School of Medicine
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