Direct targeting of proteins to lipid droplets demonstrated by time-lapse live cell imaging(BIOCHEMICAL ENGINEERING)
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概要
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A protein that specifically targets lipid droplets (LDs) was created by connecting two domains of nonstructural protein 4B containing amphipathic helices from hepatitis C virus. We demonstrated its direct targeting and accumulation to the LD surface by time-lapse live cell imaging, comparable to those observed with adipose differentiation-related protein.
- 公益社団法人日本生物工学会の論文
著者
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Tanaka Torahiko
Division Of Infectious Disease Control Advanced Medical Research Center Nihon University School Of M
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Ikeda Masanori
Department Of Electrical And Electronic Engineering College Of Engineering Nihon University
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Makishima Makoto
Division of Biochemistry, Department of Biomedical Sciences, Nihon University School of Medicine
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Kato Nobuyuki
Department of Applied Chemistry, Faculty of Engineering, Osaka University
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Ikeda Masanori
Department of Tumor Virology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
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Kuroda Kazumichi
Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine
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Shimizu Kazufumi
Division and Department of Medicine, Dentistry, Obstetrics and Gynecology, Nihon University School of Medicine
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Tanaka Torahiko
Division of Biochemistry, Department of Biomedical Sciences, Nihon University School of Medicine
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