Developmental Pattern of Urinary Ketonic Bile Acids during the Neonatal Period.

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概要

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• We tested the hypothesis that healthy neonates and infants excrete in the urine ketonic bile acids, Δ<SUB>4</SUB>-3-oxo bile acids and Δ<SUB>1</SUB>-3-oxo bile acids. The hypothesis is based on the finding of ketonic bile acids in amniotic fluid at full term. We measured the urinary concentration of ketonic bile acids during the neonatal period. Urine from 24 healthy fullterm infants (aged 3 d and 1, 2, and 3 mo, six per group) was analyzed for bile acids by gas chromatography-mass spectrometry with selected ion monitoring. Large amounts of ketonic bile acids were detected in the urine of healthy neonates and infants. The concentration of ketonic bile acids in urine at age 3 d was significantly higher than at age 1, 2, or 3 mo (P<0.01, P< 0.01, P< 0.001, respectively). This study demonstrates that healthy new-born infants excrete large amounts of ketonic bile acids in the urine.

• 久留米大学医学部 The Kurume Medical Journal 編集部の論文

著者

• Inoue Toshiro

  Department Of Bioscience And Technology Faculty Of Agriculture Iwate University

• INOUE TOSHIRO

  Department of Pediatrics and Child Health, Kurume University School of Medicine

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