Aspirin treatment and platelet function in Kawasaki disease.
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概要
- 論文の詳細を見る
The comparative effectiveness of small-dose (30 mg/kg) aspirin and highdose (150 mg/kg) in Kawasaki disease was evaluated in clinical symptoms and platelet aggregation. Twenty-three patients with Kawasaki disease were entered in the randomized study and devided into three groups. The durations of fever were 14.8± 3.5 days in the control group, 11.3 ± 2.1 d. in the small-dose group and 8.7 ± 2.3 d. in the high-dose group. The high-dose group showed a significantly shorter duration of fever (P<.01).<BR>The platelet aggregation induced by ADP in the second week of illness were 82.4 ± 11.6 % in the control group, 66.8 ± 9.6 % in the small-dose group and 88.0 ± 10.7 % in the high-dose group (69.0 ± 5.0 % in healthy children). The control group and high-dose group showed significantly increased aggregation as compared with healthy children. The platelet aggregation in small-dose group was significantly lower than that in the control group (P<.01). SGOT and SGPT elevated in half of the patients treated with high dose of aspirin. In Kawasaki disease, 30 mg/kg/day of aspirin is recommended to prevent arterial thrombi.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
-
ICHINOSE Eisei
Department of Pediatrics and Child Health Kurume University School of Medicine
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Yokoyama Takashi
Department Of Chemistry Faculty Of Science Kyushu University
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Kato Hirohisa
Department Of Cardiovascular Medicine National Center For Child Health And Development
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KATO Hirohisa
Department of Pediatrics and Child Health, Kurume University School of Medicine
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