Intracellular Cytokine Patterns of Peripheral Blood T Cells as a Useful Indicator of Activeness of Crohn's Disease
スポンサーリンク
概要
- 論文の詳細を見る
Recently, the alteration of peripheral T cells has become a focus of attention in research on Crohn's disease (CD). To examine the characteristics of peripheral T cells in CD patients, we analyzed the expression of a memory T cell marker (CD45RO^<Bright>CD3+) and the cytokine production by peripheral helper and cytotoxic T cells in patients with CD. With the use of monensin to prevent the secretion of cytokines under stimulation, we measured the count of intracellular cytokine-positive cells for production of interferon (IFN)-γ, tumor necrosis factor (TNF)-α, interleukin (IL)-2, IL-4, IL-6, IL-10, and granulocyte-macrophage colony stimulating factor (GM-CSF) in the peripheral T cell population using flow-cytometry. The counts of lymphocytes, T cells, and helper T cells in patients with CD were significantly lower than in normal volunteers. Although no difference in the counts of lymphocytes, total T cells, helper and cytotoxic T cells was observed, the counts of intracellular cytokine producing helper T cells in IFN-γ, TNF-α or GM-CSF were significantly higher in active cases than in quiescent cases. These results suggest that stable CD patients are immunosuppressive, and activation of some kinds of T-cells, especially Thl-associated cytokine producing T-cells, correlate with disease progression. Thl-associated cytokine analysis of peripheral T cells may be one of the useful markers to evaluate the activeness of Crohn's disease.
- 広島大学の論文
著者
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TAKESUE Yoshio
Department of Infection Control and Prevention, Hyogo College of Medicine
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Yokoyama Takashi
Department of Gynecologic Oncology, Shikoku Cancer Center
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Hiyama Eiso
Natural Science Center For Basic Research And Development Hiroshima University
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今村 祐嗣
京都大学生存圏研究所
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Imamura Yuji
Department Of Surgery Division Of Clinical Medical Sciences Programs For Applied Biomedicine Graduat
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Imamura Y
Research Institute For Sustainable Humanosphere Kyoto University
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Murakami Yoshiaki
Department of Electrical and Electronics Engineering, Sophia University
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Matsuura Yuichiro
広島大学 第1外科
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Sueda T
Department Of Cardiovascular Surgery Hiroshima University Hospital
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Sueda Taijiro
広島県厚生農業協同組合連合会廣島総合病院 外科
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Sueda Taijiro
Department Of Surgery Division Of Clinical Medical Science Graduate School Of Biomedical Sciences Hi
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Sueda Taijiro
Deaprtment Of Pediatric Surgery Graduate School Of Biomedical Science Hiroshima University
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Sueda Taijiro
Department Of Surgery Division Of Clinical Medical Science Graduate School Of Biomedical Science Hir
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Sueda Taijiro
Department Of Cardiovascular Surgery Hiroshima University Graduate School Of Medicine
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MATSUURA Yuichirou
First Department of Surgery Hiroshima University School of Medicine
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OGURA Yoshio
Department of Surgery, Division of Clinical Medical Sciences, Programs for Applied Biomedicine, Grad
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Yokoyama Takashi
Department Of Surgery Aki City Hospital
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Murakami Yoshiaki
Department Of Surgery Division Of Clinical Medical Science Graduate School Of Biomedical Sciences Hi
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Murakami Yoshiaki
Department Of Cardiology Jichi Medical School
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Yokoyama Takashi
Department Of Chemistry Faculty Of Science Kyushu University
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Takesue Yoshio
Department Of Infection Control And Prevention Hyogo College Of Medicine
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Matsuura Yuichiro
Department Of Surgery Division Of Clinical Medical Science Graduate School Of Biomedical Sciences Hi
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Santo Takahiro
Department Of Surgery Division Of Clinical Medical Science Graduate School Of Biomedical Sciences Hi
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Ogura Yoshio
Department Of Surgery Division Of Clinical Medical Sciences Programs For Applied Biomedicine Graduat
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Ogura Yoshio
Department Of Otolaryngology Okayama University Medical School
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Yokoyama Takashi
Department Of General Medicine Hiroshima University School Of Medicine
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Ogura Yoshio
Department of Chemistry, School of Hygienic Sciences, Kitasato University
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