Pouchitis disease activity index (PDAI) does not predict patients with symptoms of pouchitis who will respond to antibiotics
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概要
- 論文の詳細を見る
To evaluate whether the pouchitis disease activity index (PDAI) alone is sufficient to select appropriate treatment plans for ulcerative colitis patients with bowel movement problems following ileal pouch-anal anastomosis (IPAA). The study included 70 patients undergoing an IPAA. For these patients, an evaluation by PDAI was performed prospectively at 1-2 years after the ileostomy closure. When the symptoms relevant to bowel movement appeared, PDAI was evaluated and metronidazole or ciprofloxacin was administered. Pouchitis was diagnosed in patients with PDAI scores of 7 or higher. The patients whose PDAI score was less than 7 and who responded to antibiotic therapy were defined as treatment responders having disease not diagnosed by PDAI (TR-NDPDAI). Pouchitis was diagnosed in 16 of the 70 enrolled patients (22.9%) using the PDAI scoring system. Of these 16 patients, 11 had acute pouchitis and 5 had chronic pouchitis. Twenty-one patients whose PDAI score was less than 7 were symptomatic. Among them, 12 were TR-NDPDAI. In patients with TR-NDPDAI, antibiotic treatment resulted in significant improvements in the PDAI score (P < 0.001) and in clinical symptoms (P < 0.001) after treatment. Antibiotic treatment was effective in a considerable number of ulcerative colitis patients whose PDAI score was less than 7 after IPAA.
- Springerの論文
- 2009-11-01
著者
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TAKESUE Yoshio
Department of Infection Control and Prevention, Hyogo College of Medicine
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Murakami Yoshiaki
Department of Electrical and Electronics Engineering, Sophia University
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Matsuura Yuichiro
広島大学 第1外科
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Sueda T
Department Of Cardiovascular Surgery Hiroshima University Hospital
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Sueda Taijiro
広島県厚生農業協同組合連合会廣島総合病院 外科
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Sueda Taijiro
Department Of Surgery Division Of Clinical Medical Science Graduate School Of Biomedical Sciences Hi
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Sueda Taijiro
Deaprtment Of Pediatric Surgery Graduate School Of Biomedical Science Hiroshima University
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Sueda Taijiro
Department Of Surgery Division Of Clinical Medical Science Graduate School Of Biomedical Science Hir
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Sueda Taijiro
Department Of Cardiovascular Surgery Hiroshima University Graduate School Of Medicine
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MATSUURA Yuichirou
First Department of Surgery Hiroshima University School of Medicine
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Ohge Hiroki
Department Of Surgery Division Of Clinical Medical Science Graduate School Of Biomedical Sciences Hi
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Murakami Yoshiaki
Department Of Surgery Division Of Clinical Medical Science Graduate School Of Biomedical Sciences Hi
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Murakami Yoshiaki
Department Of Cardiology Jichi Medical School
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Takesue Yoshio
Department Of Infection Control And Prevention Hyogo College Of Medicine
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Matsuura Yuichiro
Department Of Surgery Division Of Clinical Medical Science Graduate School Of Biomedical Sciences Hi
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Santo Takahiro
Department Of Surgery Division Of Clinical Medical Science Graduate School Of Biomedical Sciences Hi
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KOHYAMA MOHEI
Department of Surgery, Hiroshima General Hospital
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SHIMAMOTO FUMIO
Faculty of Human Culture and Science, Prefectural University of Hiroshima
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Shimamoto F
Faculty Of Human Culture And Science Prefectural University Of Hiroshima
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Koyama Mohei
Department Of Surgery Hiroshima General Hospital
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