A study on the optimal dose of aspirin therapy in Kawasaki disease. Clinical evaluation and arachidonic acid metabolism.:Clinical Evaluation and Arachidonic acid Metabolism
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概要
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Aspirin is the basic treatment for Kawasaki disease, however its optimal dose is, controversial. We investigated the therapeutic efficacy of highdose (100 mg/kg/day, n=30) versus low-dose (30 mg/kg/day, n=30) aspirin. Duration of fever, trasaminase, plasma thromboxane B<SUB>2</SUB> (TxB<SUB>2</SUB>) and 6-ketoprostaglandin F<SUB>1α</SUB> (PGF<SUB>1α</SUB>) levels were compared before enrollment and on days 4, 7 and 14. In the high-dose group, duration of fever was significantly shorter than that of low-dose group (3.2±1.8 versus 5.4±4.3 days, p<0.05), however, serum glutamic pyruvic transaminase levels were elevated (157.4±187.7 versus 48.0±58.2I.U./liter, p<0.005). No differences in the incidence of coronary artery lesions were observed (5 of 30 versus 7 of 30). Plasma TxB<SUB>2</SUB> production was completely blocked in both groups, plasma 6-keto-PGF<SUB>1α</SUB> levels in the high-dose group on day 14 was lower than that in the low-dose group (39±26 versus 160±207 pg/ml, p<0.05). This latter observation suggest that high-dose therapy may be disadvantageous as anti-thrombotic treatment, and supports the notion that low dose therapy is safe in the acute stage of Kawasaki disease.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
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Akagi Teiji
Department Of Cardiovascular Surgery Okayama University Graduate School Of Medicine And Dentistry
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Kato Hirohisa
Department Of Cardiovascular Medicine National Center For Child Health And Development
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Sato Noboru
Department Of Anatomy Osaka University Medical School
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Inoue Osamu
Department Of Clinical And Laboratory Medicine Faculty Of Medicine University Of Yamanashi
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AKAGI TEIJI
Department of Pediatrics and Child Health, Kurume University School of Medicine
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