Calcium Pectinate Gel Bead Intended for Oral Protein Delivery: Preparation Improvement and Formulation Development
スポンサーリンク
概要
- 論文の詳細を見る
Calcium pectinate gel (CPG) micrometer-sized beads (microbeads) containing insulin, as a model amphoteric protein, were prepared by ionotropic gelation technique together with an air compressor. The influences of phosphate buffer, pH as well as calcium and pectin concentrations of cross-linking solution on the characteristics and release profiles of microbeads were investigated. With the aid of compressed air flow, the mean diameters of beads were successfully decreased to micron-sized. The results showed that all the factors investigated greatly affected the entrapment efficiencies and release profiles of the microbeads. Suitable formulation concentrations should be considered and great care should be taken to maintain the pH of working solutions at or close to isoelectric point of protein loaded during the whole preparation process. Hence, CPG microbeads of perfect spherical shape, uniform sizes, enhanced mechanical strength, good entrapment efficiencies and delayed release profiles were prepared for a load of amphoteric protein and peptide drugs, without any use of organic solvents or harsh ingredients. Therefore, CPG microbeads could be a promising carrier for oral controlled-release systems of amphoteric protein and peptide drugs.
- 公益社団法人 日本薬学会の論文
著者
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Zhao Ying
Department Of Cardiology Anzhen Hospital Capital Medical University
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Li Gao
Department Of Nucleus Medicine Qilu Hospital Of Shandong University
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Si Luqin
Department of pharmaceutics, School of Pharmacy, Tongji Medical College, Huazhong University of Scie
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Huang Jiangeng
Department of pharmaceutics, School of Pharmacy, Tongji Medical College, Huazhong University of Scie
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Li Sha
Department of pharmaceutics, School of Pharmacy, Tongji Medical College, Huazhong University of Scie
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Zhai Xuezhen
Department of pharmaceutics, School of Pharmacy, Tongji Medical College, Huazhong University of Scie
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Li Sha
Department Of Electrical And Computer Engineering University Of Saskatchewan
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Li Gao
Department Of Head And Neck Surgery Sir Run Run Shaw Hospital Zhejiang University School Of Medicine
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Huang Jiangeng
Department Of Pharmaceutical Sciences College Of Pharmacy University Of Nebraska Medical Center
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Si Luqin
Department of pharmaceutics, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology
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Li Gao
Department of pharmaceutics, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology
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Zhao Ying
Department of Biological Sciences and Biotechnology, Tsinghua University
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Zhao Ying
Department of pharmaceutics, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology
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Huang Jiangeng
Department of pharmaceutics, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology
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