Fifty-Hertz Electromagnetic Fields Decrease Frequencies of Micronuclei Induced by Mitomycin C in Newborn Rat Astrocytes
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概要
- 論文の詳細を見る
Epidemiological studies suggest that exposure to environmental and occupational electromagnetic fields (EMFs) contributes to the induction of brain tumors, leukemia, and other neoplasms. The aim of this study was to investigate the genotoxic effects of co-exposure to mitomycin C (MMC), a mutagen, and 50-Herz (Hz) EMFs, using an in vivo-ex vivo newborn rat astrocyte micronucleus assay. Three-day-old male Sprague-Dawley rats were co-exposed to 50-Hz EMFs and either 2.0 or 4.0mg/kg of MMC. Brain cells were dissociated into single cells, cultured for 96h, and stained with acridine orange and an antibody against glial fibrillary acidic protein. The frequency of micronucleated astrocytes was determined by fluorescence microscopy. The frequency of micronuclei was not increased in rat astrocytes exposed to EMFs alone. However, the frequencies of micronuclei significantly decreased in the rats exposed to 2.0 or 4.0mg/kg MMC and a 7.5 or 10 mili Tesla (mT) EMF, in comparison to those in the rats exposed to 2.0 or 4.0mg/kg MMC alone (sham-exposure, 0mT EMF) for 72h (p<0.01). Since we previously found that the same range of EMFs enhanced the genotoxicity of cisplatin in the same assay system as that used in the present study, it is suggestSed that effects of EMFs on the genotoxicities of chemicals co-exposed to rats are dependent on the chemicals.
- 日本環境変異原学会の論文
- 2006-08-31
著者
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Suzuki Yuji
Department of Pubulic Health and Environmental Mesicine,Jikei University School of Medicine
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Shimizu Hidesuke
Department of Pubulic Health and Environmental Mesicine,Jikei University School of Medicine
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Shimizu Hidesuke
Department Of Public Health And Environmental Medicine The Jikei University School Of Medicine
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YOSHIOKA Hayato
Department of Public Health and Environmental Medicine, The Jikei University School of Medicine
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TOYAMA Yoshimitsu
Department of Public Health and Environmental Medicine, The Jikei University School of Medicine
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MIYAKOSHI Yuichi
Department of Public Health and Environmental Medicine, The Jikei University School of Medicine
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Matsudaira Toru
Department of Public Health and Environmental Medicine, The Jikei University School of Medicine
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宮越 雄一
Department Of Public Health And Environmental Medicine The Jikei University School Of Medicine
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Suzuki Yuji
Department Of Public Health And Environmental Medicine The Jikei University School Of Medicine
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Yoshioka Hayato
Department Of Public Health And Environmental Medicine The Jikei University School Of Medicine
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Suzuki Yuji
Department Of Public Health And Environmental Medicine Jikei University School Of Medicine
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Toyama Yoshimitsu
Department Of Public Health And Environmental Medicine The Jikei University School Of Medicine:crimi
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冨山 吉光
Department Of Public Health And Environmental Medicine The Jikei University School Of Medicine
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Shimizu Hidesuke
Department Of Public Health And Environmental Medicine Jikei University School Of Medicine
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Matsudaira Toru
Department Of Public Health And Environmental Medicine The Jikei University School Of Medicine
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Matsudaira Toru
Department Of Medicine Division Of Diabetes And Endocrinology The Jikei University School Of Medicin
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Suzuki Yuji
Department Of Health Sciences School Of Health And Social Services Saitama Prefectural University
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Suzuki Yuji
Department Of Astronomy Kyoto University
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SUZUKI Yuji
Department of Agriculture, Graduate School of Agricultural Science, Tohoku University
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SHIMIZU Hidesuke
Department of Public Health and Environmental Medicine, Jikei University School of Medicine
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