Effect of Static Magnetic Field on the Induction of Micronuclei by Some Mutagens
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概要
- 論文の詳細を見る
Objectives: It is important to assess the risk of static magnetic fields (SMFs) on human health, because epidemiological studies have indicated that SMFs play a role in the development of diseases such as leukemia and brain tumor. In our environment, we have numerous chances to be exposed to not only SMFs but also many chemicals containing mutagens. The aim of this study is to investigate the effect of SMFs on the induction of micronuclei induced by some mutagens. Methods: BALB/c mice were exposed to 4.7 tesla (T) SMF for 24 hr immediately after the injection of carboquone (alkylating agent), colcemid (spindle poison), mitomycin C (cross-linking agent), vincristine (spindle poison), sodium fluoride (a byproduct of aluminum plants under strong SMF) or 1-ethyl-1-nitrosourea (brain tumor-, gliomas- and thymic lymphoma-inducing chemical). Results: The frequency of micronuclei induced by six mutagens increased after co-exposure to SMF. Conclusions: An additive/synergistic effect of SMF and chemicals was observed from the results of increased frequency of micronuclei induced by mutagens in mouse bone marrow erythrocytes.
- 日本衛生学会の論文
著者
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Suzuki Yuji
Department of Pubulic Health and Environmental Mesicine,Jikei University School of Medicine
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Shimizu Hidesuke
Department of Pubulic Health and Environmental Mesicine,Jikei University School of Medicine
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Shimizu Hidesuke
Department Of Public Health And Environmental Medicine The Jikei University School Of Medicine
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IKEHATA Masateru
Biotechnology Laboratory, Railway Technical Research Institute
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YOSHIOKA Hayato
Department of Public Health and Environmental Medicine, The Jikei University School of Medicine
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TOYAMA Yoshimitsu
Department of Public Health and Environmental Medicine, The Jikei University School of Medicine
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MIYAKOSHI Yuichi
Department of Public Health and Environmental Medicine, The Jikei University School of Medicine
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宮越 雄一
Department Of Public Health And Environmental Medicine The Jikei University School Of Medicine
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Suzuki Yuji
Department Of Public Health And Environmental Medicine The Jikei University School Of Medicine
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Yoshioka Hayato
Department Of Public Health And Environmental Medicine The Jikei University School Of Medicine
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Ikehata Masateru
Biotechnology Laboratory Railway Technical Research Institute
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Suzuki Yuji
Department Of Public Health And Environmental Medicine Jikei University School Of Medicine
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IKEHATA Masateru
Department of Public Health and Environmental Medicine, Jikei University School of Medicine
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Toyama Yoshimitsu
Department Of Public Health And Environmental Medicine The Jikei University School Of Medicine:crimi
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冨山 吉光
Department Of Public Health And Environmental Medicine The Jikei University School Of Medicine
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Shimizu Hidesuke
Department Of Public Health And Environmental Medicine Jikei University School Of Medicine
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Suzuki Yuji
Department Of Health Sciences School Of Health And Social Services Saitama Prefectural University
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Ikehata Masateru
Department Of Public Health And Environmental Medicine Jikei University School Of Medicine
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Ikehata Masateru
Biotech. Lab. Environ. Engineer. Div. Railway Tech. Res. Inst.
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Suzuki Yuji
Department Of Astronomy Kyoto University
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SUZUKI Yuji
Department of Agriculture, Graduate School of Agricultural Science, Tohoku University
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SHIMIZU Hidesuke
Department of Public Health and Environmental Medicine, Jikei University School of Medicine
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