Effect of Dimethyl Sulfoxide on Natural Resistance to Bacterial Infections in Mice

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Dimethyl sulfoxide (DMSO), administered intraperitoneally (i. p.) immediately before bacterial challenge, shortened the survival time of mice infected i. p. with a lethal dose of Salmonella enteritidis NUB 1 (virulent strain) and increased the mortality rate for mice infected i. p. with various bacterial strains showing low virulence for mice, such as S. enteritidis NUB 31 (avirulent strain), Pseudomouas aeruginosa, Klebsiella pneumoniae and Streptococcus pyogenes. It was revealed that DMSO enhanced multiplication of S, enteritidis NUB 1 or facilitated the survival of S. enteritidis NUB 31 in the bodies of mice. At 30hr after infection with S. enteritidis NUB 1 or NUB 31, most of the viable bacteria contained in the peritoneal fluid were recovered from cells in mice treated with DMSO as well as in untreated mice. There was no evidence that DMSO exerted any direct effect on microorganisms to stimulate in vitro growth or to enhance their virulence for mice. Ingestion by phagocytes of S. enteritidis NUB 1 injected i. p. or intravenously was not inhibited by DMSO. Although DMSO caused a transient decrease in the number of peritoneal macrophages, the enhancing effect of DMSO on infection did not appear to be solely due to a decrease of peritoneal macrophages. The effect of DMSO was highest when it was administered within one hour before or simultaneously with the bacterial challenge. The acceleration of deaths of mice infected with S. enteritidis NUB 1 by DMSO was also observed when the two agents were given orally.
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Effect of Dimethyl Sulfoxide on Natural Resistance to Bacterial Infections in Mice

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