LIVER VITAMIN B12 LEVELS IN CHRONIC LIVER DISEASES

概要

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Range and average values were determined for the vitamin B12 levels of the liver tissues obtained at laparotomy from 35 patients with chronic liver diseases and from 18 patients with peptic ulcer or gastroptosis. In cirrhosis the average value was 0.19μg per g, in cancer of the liver possibly developed from cirrhosis 0.13μg per g, in Banti's syndrome 0.62μg per g, and in peptic ulcer and gastroptosis 0.74μg per g. In cirrhosis and Banti's syndrome the liver B12 levels of the cases receiving parenterally B12 did not rise significantly with a few exceptions, the average values remaining on the similar levels described above.Following the operation of portacaval anastomosis the liver B12 levels of the patients with cirrhosis or Banti's syndrome fell even during parenteral administration of the vitamin. The fall following the operation was not remarkable in cases whose pre-operation levels of the liver B12 were low.
日本ビタミン学会の論文