Reductive Transformation of Benzoate by Nocardia asteroides and Hormoconis resinae

概要

論文の詳細を見る
A variety of substituted aromatic acids were reduced to the corresponding alcohols by Nocardia asteroides JCM3016 under aerobic conditions. An isolated mold, Hormoconis resinae F328,could also reductively transform benzoate, the erythro isomer of (1R, 2S)-1-phenyl-1,2-propanediol being yielded as well as benzyl alcohol. C-1 of the diol was found to be derived from the α-carbon of benzoate by ^<13>C-NMR analysis. The acyloin condensation between pyruvate and benzaldehyde formed from benzoate is assumed to participate in the diol formation. An ATP-dependent and NADPH-linked benzoate reductase (EC 1.2.1.30) and an NADPH-linked benzaldehyde reductase (EC 1.1.1.91) were demonstrated to participate in the benzoate reduction in both N. asteroides JCM 3016 and H. resinae F328.
社団法人日本生物工学会の論文
1990-04-25