Structural Identification of a New Tri-p-coumaroylspermidine with Serotonin Transporter Inhibition from Safflower

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概要

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• We previously reported that safflower (Carthamus tinctorius L.) ethyl acetate extract (HE) possessed an inhibitory action on serotonin (5HT) uptake in Chinese hamster ovary (CHO) cells expressing 5HT transporter (SERT) (S6 cells). Here, HE was adopted to go through an activity-guided isolation, and then an ingredient with potent SERT inhibitory action was obtained, which was elucidated as N1,N5-(Z)-N10-(E)-tri-p-coumaroylspermidine (CX), a new coumaroylspermidine analog, by using spectroscopic methods including extensive 1D- and 2D-NMR analyses. Preliminary pharmacological study demonstrated that CX was a potent SERT inhibitor.

著者

• Zhao Gang

  Cell Star Bio-Technologies Co., Limited

• Qin Guo-Wei

  Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences

• Gai Yue

  Cell Star Bio-Technologies Co., Limited

• Guo Li-He

  Cell Star Bio-Technologies Co., Limited

• Zhao Gang

  Dep. Of Neurology Xijing Hospital The Fourth Military Medical Univ.

• Qin Guo-wei

  Shanghai Inst. Of Materia Medica Shanghai Institutes For Biological Sciences

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