The Effects of Repeated Administration of 7,12-Dimethylbenz[a]anthracene on the Induction of Mammary Carcinomas and Dysplasias in Rats
スポンサーリンク
概要
- 論文の詳細を見る
The aim of this study was to investigate the effects of repeated administrations of relatively low doses of 7,12-dimethylbenz[a]anthracene (DMBA) on the induction of mammary carcinomas (MCs) and dysplasias (MDs) in rats. DMBA at 0, 0.1, 0.2, 0.5 and 1 mg for female rats, and at 0, 0.5, 1 and 2 mg for male rats was administered twice weekly after weaning. In female rats, repeated administration of 1 mg DMBA induced MCs while 0.1 mg DMBA induced MDs in all animals. The incidence of MCs increased and the latent period shortened while the incidence of MDs decreased in a dose-dependent manner. In male rats, repeated administration of 2 mg DMBA induced MCs in all animals. The incidence of MCs increased and the latent period shortened in a dose-dependent manner while the incidence of MDs increased by repeated administration of 1 mg DMBA. These results suggest that the total exposure of chemical carcinogens may be responsible for the induction of MCs or MDs, and that MDs may be more dependent on female sex hormones than MCs.
- 日本毒性病理学会の論文
- 2008-06-30
著者
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永田 良一
Shin Nippon Biomedical Laboratories, Ltd.
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Yoshida Hiroki
Department Of Biomolecular Sciences Faculty Of Medicine Saga University
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Nagata Ryoichi
Shin Nippon Biomedical Laboratories (snbl) Ltd.
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永田 良一
Shin Nippon Biomedical Laboratories Ltd.
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Kawaguchi Hiroaki
Department Of Inf. Science Shonan Institute Of Technology
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吉田 浩己
The Department Of Pathology I Faculty Of Medicine Kagoshima University
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Hori Takao
Department Of Anesthesiology Saitama Medical School
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Umekita Yoshihisa
Department Of Pathology Faculty Of Medicine Kagoshima University
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Hori Takao
Department Of Tumor Pathology Field Of Oncology Kagoshima University Graduate School Of Medical And
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Umekita Yoshihisa
Department Of Tumor Pathology Field Of Oncology Kagoshima University Graduate School Of Medical And
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Yoshida Hiroki
President Kagoshima Univ. Jpn
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Nagata Ryoichi
Shin Nippon Biomedical Laboratories Ltd. Jpn
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Nagata Ryoichi
Shin Nippon Biomedical Lab. Ltd.
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Kawaguchi Hiroaki
Department Of Veterinary Experimental Animal Science Faculty Of Agriculture Kagoshima University
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Hirakawa Kimiaki
鹿児島大学 農学部実験動物学
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YOSHIDA Hiroki
Department of Biochemistry, Microbiology, and Clinical Pharmacy, Graduate School of Clinical Pharmacy, Kyushu University of Health and Welfare
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