A Case of Adult Autoimmune Hepatitis with Histological Features of Giant Cell Hepatitis
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概要
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Giant cell hepatitis is rare in adult patients. This form of hepatitis shows fast progression to cirrhosis. A 65-year-old woman was admitted to our hospital with jaundice. She was negative for hepatitis virus markers and positive for antinuclear antibodies. We diagnosed her as autoimmune hepatitis. Liver biopsy findings revealed typical features of interface hepatitis and giant cell hepatitis. Giant cells were positive for keratin 8/18, but not for keratin 19, keratin 7 or Ki-67. These results suggest that giant cell formation is associated with the fusion of matured hepatocytes rather than the active proliferation of immature cells.
著者
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SASAGURI Yasuyuki
Department of Pathology, Kurume University School of Medicine
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Abe Shintaro
Third Department Of Internal Medicine University Of Occupational And Environmental Health Japan Scho
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Tanimoto Akihide
Department of Molecular and Cellular Pathology, Kagoshima University Graduate School of Medical and
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Hayashi Hiroki
Third Department of Internal Medicine, University of Occupational and Environmental Health, Japan, S
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Narita Ryoichi
Third Department of Internal Medicine, University of Occupational and Environmental Health, Japan, S
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Hiura Masaaki
Third Department of Internal Medicine, University of Occupational and Environmental Health, Japan, S
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Tabaru Akinari
Third Department of Internal Medicine, University of Occupational and Environmental Health, Japan, S
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Harada Masaru
Third Department of Internal Medicine, University of Occupational and Environmental Health, Japan, S
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Sasaguri Yasuyuki
Department Of Pathology And Cell Biology School Of Medicine University Of Occupational And Environme
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Hiura Masaaki
Third Department Of Internal Medicine University Of Occupational Environmental Health
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Tabaru Akinari
Third Department Of Internal Medicine University Of Occupational And Environmental Health Japan Scho
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Narita Ryoichi
Third Department Of Internal Medicine University Of Occupational And Environmental Health Japan Scho
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Harada Masaru
Third Department Of Internal Medicine University Of Occupational And Environmental Health
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Tanimoto Akihide
Department Of Molecular And Cellular Pathology Kagoshima University Graduate School Of Medical And D
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Tanimoto Akihide
Department of Pathology and Cell Biology, University of Occupational and Environmental Health, Japan, School of Medicine, Japan
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Abe Shintaro
Third Department of Internal Medicine, University of Occupational and Environmental Health, Japan, School of Medicine, Japan
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Hayashi Hiroki
Third Department of Internal Medicine, University of Occupational and Environmental Health, Japan, School of Medicine, Japan
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Tabaru Akinari
Third Department of Internal Medicine, University of Occupational and Environmental Health, Japan, School of Medicine, Japan
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Harada Masaru
Third Department of Internal Medicine, University of Occupational and Environmental Health, Japan, School of Medicine, Japan
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