A Novel Adult T Cell Leukemia-Derived Cell Line (SALT-3) Susceptible to Human Immunodeficiency Virus type 1 Infection
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概要
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A novel human T cell line (SALT-3) was established from the pleural effusion of a patient with adult T cell leukemia (ATL) of lymphoma type. SALT-3 showed atypical T cell markers such as CD1<SUP>-</SUP>CD2<SUP>-</SUP>CD3<SUP>-</SUP>CD4<SUP>+</SUP>CD5<SUP>+</SUP>CD7<SUP>+</SUP>CD8<SUP>-</SUP>CD19<SUP>-</SUP>CD20<SUP>-</SUP>CD25<SUP>+</SUP>HLA-DR<SUP>+</SUP>. T cell receptor α/β and γ/δ were undetectable. Human T cell lymphotropic virus type 1 (HTLV-I) particles were seen on SALT-3 cells by electron microscopic analysis. HTLV-I gag p19, proviral DNA and mRNA of HTLV-I genes were also detected in the cells. Chromosome analysis showed abnormal karyotypes as 47, XY, partial trisomy of No. 3 chromosome, and trisomy of No. 7 chromosome. Furthermore, SALT-3 were susceptible to the infection of human immunodeficiency virus type 1 (HIV-1) and the cells were rapidly killed after HIV-1 infection. This newly established HTLV-I-infected human T cell line would be a useful tool to study biological activities of atypical type of ATL cells and to examine the cytotoxic effects of HIV-1 and its modulators.
著者
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Sadamori Naoki
Department Of Internal Med.
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Sasaguri Yasuyuki
Department Of Pathology And Cell Biology School Of Medicine University Of Occupational And Environme
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Sagawa Kimitaka
Department Of Laboratory Medicine Kurume University Hospital
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SASAGURI YASUYUKI
Department of Pathology,University of Occupational and Environmental Health School of Medicine
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KOGA TRRUHITO
Department of Medicine, Koga Hospital
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