Murine Monoclonal Antibodies (MCS-1 and MCS-2) Reactive with Human Myeloid Leukemia Cells
スポンサーリンク
概要
- 論文の詳細を見る
In an attempt to identify the antigens expressed on human myeloid leukemia cells, two murine monoclonal antibodies (mAb) designated as MCS-1 (isotype; IgG3) and MCS-2 (IgG1) were raised. MCS-1 reacted with peripheral blood granulocytes, but not with monocytes, whereas MCS-2 reacted with both granulocytes and monocytes. The incidence of MCS-1 and MCS-2 reactivity with the cells from a total of 121 patients with various type of leukemias was as follows: 25/46 (54%) and 39/47 (83%) in acute myeloblastic leukemia and acute monoblastic leukemia, 8/16 and 16/16 in chronic myeloid leukemia in blastic crisis (CML-BC) of myeloid type, 0/7 and 2/7 in CML-BC of lymphoid type, 0/26 and 2/32 in acute lymphoblastic leukemia (ALL), 7/7 and 7/7 in chronic phase of CML, respectively. Two cases of MCS-2 positive ALL had a Philadelphia chromosome marker (Ph<SUP>1</SUP>). In contrast, neither MCS-1 nor MCS-2 reacted with lymphocytes or any of leukemic and non-leukemic lymphoid cell lines tested. These results indicate that MCS-1 and MCS-2 mAb recognized two different differentiation antigens expressed on granulocytes and monocytes. These mAb would be useful reagents to determine differentiation antigens on the cells in granulocyte and monocyte lineage.
著者
-
Peiper Stephen
Department Of Pathology Medical College Of Georgia
-
Gouhara Rumi
Department Of Chemistry Faculty Of Science And Engineering Saga University
-
Sagawa Kimitaka
Department Of Laboratory Medicine Kurume University Hospital
-
SUDO TAKAO
Department of Immunology, Kurume University School of Medicine
-
TATSUMI EIJI
Department of Molecular Immunology, New York State Department of Health, Roswell Park Cancer Institute
-
MINOWADA JUN
Department of Molecular Immunology, New York State Department of Health, Roswell Park Cancer Institute
関連論文
- Development of the Chemokine Receptor CXCR4 Antagonists as Multi-Pharmaceutical Agents Involving a New Class of Low Molecular Weight Antagonists
- P-423 Structure-Activity Relationship Studies on Cyclic Peptide-Based CXCR4 Antagonists
- Synthesis and Biological Evaluation of Peptidomimetic Analogs of the CXCR4 Antagonist FC131
- New Leads of Low Molecular Weight CXCR4 Antagonists Based on Enhancement of the T140-based Pharmacophores
- A New Strategy for Molecular-size Reduction of Bioactive Peptide, Using Two Orthogonal Libraries of Cyclic peptides
- Novel molecular mechanisms of dendritic cell-induced T cell activation
- Cytokine Production by T Cells Infiltrating in the Eye of Uveitis Patients
- Induction of MAGE Genes in Lymphoid Cells by the Demethylating Agent 5-Aza-2'-deoxycytidine
- In Vitro Effects of Immunosuppressive Agents on Cytokine Production by HTLV-I-Infected T Cell Clones Derived from the Ocular Fluid of Patients with HTLV-I Uveitis
- Melanocyte lysis by cytotoxic T lymphocytes recognizing the MART-1 melanona antigen in HLA-A2 patients with Vogt-Koyanagi-Harada disease
- Synthesis and Application of Novel Fluorescence-Labeled CXCR4 Antagonists
- Development of Low Molecular Weight CXCR4 Antagonists by Exploratory Structural Tuning of Cyclic Tetrapeptide-scaffolds
- Characteristic Features of QRST Integral Mapping in Patients With High Risk Brugada Syndrome
- Comparison of two control measures of weatherstripping in reducing blowing dust during hospital renovations
- Monoclonal Antibodies (NU-T1 and NU-T2) Recognizing Antigens Expressed on Human T Cells
- Murine Monoclonal Antibodies (MCS-1 and MCS-2) Reactive with Human Myeloid Leukemia Cells
- A Novel Adult T Cell Leukemia-Derived Cell Line (SALT-3) Susceptible to Human Immunodeficiency Virus type 1 Infection
- Ultrasonic Relaxations in Aqueous Solutions of Piperidine and Pyrrolidine