Multimodal Approaches Including Three-dimensional Conformal Re-irradiation for Recurrent or Persistent Esophageal Cancer : Preliminary Results
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概要
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The purpose of this study was to assess the toxicity and efficacy of multimodal approaches, including three-dimensional conformal re-irradiation, for patients with recurrent or persistent esophageal cancer after radiotherapy. Thirty-one patients with esophageal cancer treated with three-dimensional conformal re-irradiation were retrospectively analyzed. Of the 31 patients, 27 patients received concurrent chemotherapy, and 14 patients underwent regional hyperthermia during the re-irradiation. We divided the patients into two groups on the basis of their clinical condition: the curative group (n = 11) or the palliative group (n = 20). Severe toxicities were detected in one patient with Grade 3 esophageal perforation in the curative group, and 5 patients had a Grade 3 or higher toxicity of the esophagus in the palliative group. Advanced T stage at the time of re-irradiation was found to be significantly correlated with Grade 3 or higher toxicity in the esophagus. For the curative group, 10 (91%) of 11 patients had an objective response. For the palliative group, symptom relief was recognized in 8 (57%) of 14 patients with obvious swallowing difficulty. In conclusion, in the curative group with early-stage recurrent or persistent esophageal cancer, the multimodal approaches, including three-dimensional conformal re-irradiation, may be feasible, showing acceptable toxicity and a potential value of promising results, although further evaluations especially for the toxicities of the organs at risk are required. In the palliative group, the benefit of our therapy may be restrictive because severe esophageal toxicities were not uncommon in the patients with advanced T stage at the time of re-irradiation.
- 2011-11-16
著者
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今田 肇
産業医科大学放射線科
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今田 肇
戸畑共立病院がん治療センター
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YAMAGUCHI KOJI
First Department of Surgery Kyushu University Faculty of Medicine
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Harada Masaru
Third Department Of Internal Medicine University Of Occupational And Environmental Health Japan Scho
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OHGURI TAKAYUKI
Department of Radiology, University of Occupational and Environmental Health
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YAHARA KATSUYA
Department of Radiology, University of Occupational and Environmental Health
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IMADA HAJIME
Department of Cancer Therapy Center, Tobata Kyoritsu Hospital
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大栗 隆行
Department Of Radiology University Of Occupational And Environmental Health
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矢原 勝哉
Department Of Radiology University Of Occupational And Environmental Health
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Moon Seung
Department Of Physics Seoul National University
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HIGURE AIICHIRO
First Department of Surgery, University of Occupational and Environmental Health
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Higure Aiichiro
First Department Of Surgery University Of Occupational And Environmental Health
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Yoshikawa Ichiro
Third Department Of Internal Medicine University Of Occupational And Environmental Health Japan Scho
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Korogi Yukunori
Department Of Radiology Kumamoto University Hospital
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YAMAGUCHI Shinsaku
Department of Radiology, University of Occupational and Environmental Health
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Yamaguchi Shinsaku
Department Of Radiology University Of Occupational And Environmental Health
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Yamaguchi Koji
First Department Of Surgery University Of Occupational And Environmental Health
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Harada Masaru
Third Department Of Internal Medicine University Of Occupational And Environmental Health
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Yoshikawa Ichiro
Third Department Of Internal Medicine University Of Occupational And Environmental Health
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Moon Seung
Department Of Radiology University Of Occupational And Environmental Health
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Korogi Yukunori
Dep. Of Radiology Univ. Of Occupational And Environmental Health
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Imada Hajime
Department Of Cancer Therapy Center Tobata Kyoritsu Hospital
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Imada H
Dep. Of Cancer Therapy Center Tobata Kyoritsu Hospital
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Moon Seung
Department of Electrical Engineering, Korea University, Seoul 136-701, Korea
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