Effects of Milrinone on Hemodynamics and Regional Blood Flow in the Hypoxic Dog.
スポンサーリンク
概要
- 論文の詳細を見る
Milrinone, a therapeutic agent for acute congestive heart failure, has both inotropic and vasodilatory effects, but investigations of these effects of milrinone were almost all conducted under normoxia, and few reports have investigated how milrinone affects the hemodynamics and redistribution of regional blood flow under severe hypoxia. By using colored microspheres, we investigated how milrinone affects hemodynamics and the redistribution of regional blood flow under severe hypoxia. Twelve healthy mongrel dogs were divided into 2 groups. The milrinone group was infused with milrinone cumulatively at 25, 75 and 250 μg/kg for 5 min each. The intact group was infused with saline instead of milrinone. We measured the hemodynamics and cerebrum, cerebellum and kidney blood flow in both groups. Both groups were inspired with 10% oxygen. Milrinone induced significant decrease in mean pulmonary artery and pulmonary vascular resistance, compared with the intact group. In both groups slight decreases in mean arterial pressure, systemic vascular resistance and double-product were seen. In regional blood flow, milrinone-induced increases in blood flow were seen in the cerebrum, cerebellum, and especially in the kidneys. Milrinone's vasodilatory effects were sufficient even under hypoxia. And milrinone increased regional blood flow slightly in the cerebrum and cerebellum, and significantly in the kidneys. These results suggested that milrinone protects against hypoxia-induced organ damage especially in the kidneys. In addition, milrinone is very potent in improving severe congested hemodynamics which complicates hypoxic pulmonary vasoconstriction.
- 公益社団法人 日本獣医学会の論文
著者
-
Misumi Kazuhiro
Laboratory Of Veterinary Surgery Department Of Veterinary Medicine Faculty Of Agriculture Kagoshima
-
Sakamoto Hiroshi
Laboratory Of Biochemistry Department Of Chemistry Faculty Of Science Kyushu University
-
Ota Hiromi
Laboratory Of Pesticide Chemistry Faculty Of Agriculture Kyushu University
-
MIURA Naoki
Laboratory of Veterinary Diagnostic Imaging, Department of Veterinary Medicine, Joint Faculty of Veterinary Medicine, Kagoshima University, 1–21–24 Korimoto, Kagoshima 890–0065, Japan
-
SETOYAMA Kentaro
Laboratory of Veterinary Surgery, Department of Veterinary Medicine, Faculty of Agriculture, Kagoshima University
-
FUJIKI Makoto
Laboratory of Surgery, Joint Faculty of Veterinary Medicine, Kagoshima University
-
OTA Hiromi
Laboratory of Veterinary Surgery, Department of Veterinary Medicine, Faculty of Agriculture, Kagoshima University
関連論文
- Discrepancy between Doppler and Catheter Measurements of Pressure Gradients across Small-size Prosthetic Valve
- Assessment of Optimal Atrioventricular Delay Using Doppler Index in Atrioventricular Sequential Pacing
- Sudden Death during Holter Electrocardiogram Monitoring in a Patient with Variant Angina
- Chaotic Musical Murmur in Aortic Regurgitation
- Smooth Muscle Cell Proliferation in the Arterial Intima after Stretch Injury: Relationship between the Severity of Stretching and Intime Hyperplasia in New Zealand White Rabbits
- MYOCARDIAL INFARCTION INDUCED BY CORONARY VENOUS THROMBOSIS : An Experimental Study
- Salt Water Promotes Hypertension in Dahl-S Rats
- Fine Structure of the Parotid Gland in Tree Shrew (Tupaia glis)
- EXPERIMENTAL STUDY OF ACUTE CORONARY SINUS THROMBOSIS : Clinical References to Coronary Sinus Thrombosis and Coronary Venography
- Phosphorylation Influences The Association of p53 Tetramers
- Inactivation of Gramicidin S by Acylation of Two Ornithine Residues with Higher Fatty Acids
- Development of Atherosclerotic Lesions in Cholesterol-loaded Rabbits
- The Effects of Medetomidine on Maternal and Fetal Cardiovascular and Pulmonary Function, Intrauterine Pressure and Uterine Blood Flow in Pregnant Goats
- Relationship between Arterial and End-Tidal Carbon Dioxide Pressure during Controlled Ventilation in Porcine Neonates
- Effects of a Calcium Antagonist(Nicardipine) on Cardiovascular Function in Goats
- Effects of Olprinone on Myocardial Ischemia-Reperfusion Injury in Dogs
- Smooth Muscle Cell Proliferation in the Arterial Intima after Stretch Injury: Relationship between the Severity of Stretching and Intima Hyperplasia in New Zealand White Rabbits
- Syntheses and Biological Activities of 3-Fluoropropionic Acid Derivatives and Related Compounds
- Detection of antibodies against Fusobacterium necrophorum and Porphyromonas levii-like species in dairy cattle with papillomatous digital dermatitis
- Microminipig, a Non-rodent Experimental Animal Optimized for Life Science Research : Novel Atherosclerosis Model Induced by High Fat and Cholesterol Diet
- CT and MRI Imaging Diagnosis of Epidural Idiopathic Sterile Pyogranulomatous Inflammation in a Dog Spinal Canal
- Abnormal Erythroid Cell Proliferation and Myelofibrosis in a Cat
- Cross-Reactivity of the Anti-Human D-Dimer Monoclonal Antibody 1C9-6F10 to Canine Fibrin Degradation Products
- Opioid activities of morphiceptin analogs derived from human .BETA.-casein.
- Generalized Alopecia with Vasculitis-Like Changes in a Dog with Babesiosis
- Dipeptide Side Chain-Side Chain Hydrophobic Interactions as Conformational Core for Chymotrypsin Inhibition.
- Molecular Cloning of Canine nm23 cDNAs and Their Expression in Normal and Tumor Tissues
- Tensile Force of Pacing Lead Extraction. A Comparison between Tined Type and Screw-in Type.:A Comparison between Tined Type and Screw-in Type
- Ganglion Cysts Arising from a Canine Stifle Joint
- Effects of Milrinone on Hemodynamics and Regional Blood Flow in the Hypoxic Dog.
- α,β-Unsaturated Carboxylic Acid Derivatives. X. The Synthesis and Reaction of α-Azido-diethoxyphosphinyl-α- and β-alkenes