Cross-Reactivity of the Anti-Human D-Dimer Monoclonal Antibody 1C9-6F10 to Canine Fibrin Degradation Products

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概要

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• The cross-reactivity of the anti-human D-dimer antibody 1C9-6F10 to the canine D-dimer was evaluated by western blotting using purified canine fibrinogen, fibrin degradation products (XDPs) and plasma from a dog with suspected disseminated intravascular coagulation (DIC). The antibody cross-reacted with canine XDPs and plasma from the dog with suspected DIC. A latex agglutination assay using 1C9-6F10 measured the canine XDPs in dogs. In conclusion, the antibody 1C9-6F10 cross-reacted to the canine D-fragment with high specificity, but lower affinity compared with the human D-dimer. The latex agglutination assay using the 1C9-6F10 antibody was used to measure canine plasma D-dimer concentrations.

著者

• MOMOI Yasuyuki

  Laboratory of Diagnostic Imaging, Joint Faculty of Veterinary Medicine, Kagoshima University, 1–21–24 Korimoto, Kagoshima 890–0065, Japan

• MIURA Naoki

  Laboratory of Veterinary Diagnostic Imaging, Department of Veterinary Medicine, Joint Faculty of Veterinary Medicine, Kagoshima University, 1–21–24 Korimoto, Kagoshima 890–0065, Japan

• FURUKAWA Makoto

  Laboratory of Diagnostic Imaging, Department of Veterinary Science, Faculty of Agriculture, Kagoshima University, 1–21–24 Korimoto, Kagoshima 890–0065, Japan

• MAGARI Yasuo

  Q-may Laboratory Corporation, 11–4 Hanazono Furugou, Oita 870–0846, Japan

• MOMOI Yasuyuki

  Laboratory of Diagnostic Imaging, Department of Veterinary Medicine, Joint Faculty of Veterinary Medicine, Kagoshima University, 1–21–24 Kohrimoto, Kagoshima 890–0065, Japan

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