Effects of Olprinone on Myocardial Ischemia-Reperfusion Injury in Dogs
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概要
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We investigated the effect of olprinone on canine myocardial pump function and myocardial damage after ischemia-reperfusion injury. Three dogs of the experimental group were given olprinone (Olprinone group) and another 3 dogs were served as control (Intact group). All animals were occluded left anterior descending artery for 60 min, followed by 6 hr of reperfusion. In the experiment, hemodynamics, infarct area, creatine kinase and troponin-I were measured. Olprinone infusion induced significantly high cardiac output value and significantly low values in left ventricular end diastolic pressure and systemic vascular resistance index after reperfusion. Also, olprinone tend to attenuate the infarct area, creatine kinase and troponin-I.
著者
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MIYAHARA Kenkichi
Division of Cardiology Shinkyo Hospital
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KAMIMURA Ryozo
Frontier Science Research Center, Kagoshima University
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SETOYAMA Kentaro
Frontier Science Research Center, Kagoshima University
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Misumi Kazuhiro
Laboratory Of Veterinary Surgery Department Of Veterinary Medicine Faculty Of Agriculture Kagoshima
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Setoyama Kentaro
Frontier Schience Research Center Kagoshima University
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Sakamoto Hiroshi
Laboratory Of Biochemistry Department Of Chemistry Faculty Of Science Kyushu University
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FUJIKI Makoto
Laboratory of Surgery, Joint Faculty of Veterinary Medicine, Kagoshima University, 1–21–24 Korimoto, Kagoshima 890–0065, Japan
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FUJIKI Makoto
Laboratory of Surgery, Joint Faculty of Veterinary Medicine, Kagoshima University
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