Relationship Between intracoronary Thrombolysis and Fibrino-coagulation : Special Reference to TAT/PIC and FPA/PIC
スポンサーリンク
概要
- 論文の詳細を見る
To clarify the relationship between the results of intracoronary thrombolytic therapy(ICT)and fibrino-coagulation in patients with acute myocardial infarction(AMI), the thrombin-antithrombin III complex(TAT)and fibrinopeptide A(FPA), as indices of accelerated coagulation, and the plasmin-α2-plasmin inhibitor complex(PIC), as an index of accelerated fibrinolysis in peripheral blood, were measured just before and after heparin injection(5, 000U), and immediately after ICT. Twenty-four patients with AMI were divided into 2 groups according to the results of ICT ; successful ICT(group S)and unsuccessful ICT(group F). As a control group(group C), 14 age-matched normal volunteers were also studied. The levels of TAT and FPA before ICT were significantly higher in groups S and F than in group C(p<0.01). The TAT level before ICT in group F was higher than that in group S(p=0.07), however, the TAT, FPA and PIC levels showed no significant differences between groups S and F at each sampling time. TAT / PIC before ICT was significantly higher in group F than in group S(F : 0.026±0.020vs S : 0.008±0.004, p<0.05), whereas there was no remarkable difference in FPA / PIC between groups S and F. These results indicate that hyper-coagulation had occurred in the AMI cases and that coagulation had been more accelerated in group F. TAT / PIC might be an index of the equilibrium of the fibrino-coagulating system. Therefore, TAT / PIC measurement before thrombolytic therapy may be more useful than TAT measurement alone for evaluating recanalization in ICT.
- 社団法人日本循環器学会の論文
- 1996-02-20
著者
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Sonoda Masahiro
Second Department of Cardiology, Kagoshima Medical Center, National Hospital Organization
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MIYAHARA Kenkichi
Division of Cardiology Shinkyo Hospital
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Sonoda Masahiro
Second Department Of Cardiology Kagoshima Medical Center National Hospital Organization
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Sonoda Masahiro
2nd Division Of Cardiovascular Medicine National Hospital Organization Kagoshima Medical Center
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Sanada Jun-ichi
The 2nd Dep. of Int. Med., Kagoshima Univ. School of Medicine
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Miyauchi Taiki
Miyauchi Clinic
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MIYAHARA Kenkichi
Sinkyo Hospital
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Sonoda Masahiro
The Second Department Of Cardiology Kyushu Cardiovascular Center
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Miyauchi Taiki
The 2nd Dep. Of Internal Medicine, Kagoshima University
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Arima Terukatsu
The 2nd Dep. Of Internal Medicine, Kagoshima University
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Miyahara Kenkichi
Department Of Cardiology And Cardiovascular Surgery Shinkyo Hospital
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Miyahara Kenkichi
The Second Department Of Internal Medicine Kagoshima University School Of Medicine
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Arima Terukatsu
The 2nd Department Of Internal Medicine School Of Medicine Kagoshima University
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Miyauchi Taiki
The 2nd Department Of Internal Medicine School Of Medicine Kagoshima University
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Uenomachi Hitoshi
The 2nd Department of Internal Medicine, School of Medicine, Kagoshima University
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Sonoda masahiro
The 2nd Department of Internal Medicine, School of Medicine, Kagoshima University
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Harubyu narihito
The 2nd Department of Internal Medicine, School of Medicine, Kagoshima University
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Nagata Hideho
The 2nd Department of Internal Medicine, School of Medicine, Kagoshima University
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Sanada Jun-ichi
The 2nd Department Of Internal Medicine School Of Medicine Kagoshima University
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Sonoda Masahiro
The 2nd Department Of Internal Medicine School Of Medicine Kagoshima University
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Arima Terukatsu
The Second Department Of Internal Medicine Faculty Of Medicine Kagoshima University
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Nagata Hideho
The 2nd Department Of Internal Medicine School Of Medicine Kagoshima University
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Miyauchi Taiki
The 2nd Dep. Of Internal Medicine Faculty Of Medicine Kagoshima University
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Harubyu Narihito
The 2nd Department Of Internal Medicine School Of Medicine Kagoshima University
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Uenomachi Hitoshi
The 2nd Department Of Internal Medicine School Of Medicine Kagoshima University
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Miyahara Kenkichi
Department Of Cardiology Shinkyo Hospital
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Miyahara Kenkichi
The Second Dept. Of Intern. Med. Kagoshima Univ. School Of Med.
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