RISK FACTORS IN NORMOLIPIDEMIC MALE PATIENTS WITH CORONARY ARTERY DISEASE IN JAPANESE

概要

論文の詳細を見る
We examined serum lipids, lipoproteins, apolipoproteins (Apo), lipoprotein(a) (Lo(a)), C4b-binding protein (C4dp) and lathosterol in 22 normolipidemic (serum total cholesterol <220 mg/dl and serum triglycerides < 150 mg/dl) male patients with coronary artery disease (CAD) and 33 normal male subjects. Many of the patients in the CAD group with normal total cholesterol (T-Ch) and triglycerides (TG) had higher TG, low-density lipoprotein (LDL)-Ch, β-lipoprotein (Lipo) and Apo B values and lower high-density lipoprotein (HDL)-Ch. Apo A-I and Apo A-II values than those of the control group. Differences were also observed in the β-Lipo/HDL-Ch. Apo B/Apo A-I, and HDL-Ch ratios and the atherogenic index [A.I.=(T-Ch-HDL-Ch)/HDL-Ch], all of which are generally accepted as indices for atherosclerosis. Even in CAD patients with normolipidemia, the HDL-Ch/T-Ch ratio and A.I. seemed to be important risk factors. In addition, Lo(a) and lathosterol, an accepted indicator of whole-body cholesterol synthesis, were higher in the CAD group. The CAD group also appeared to have a higher C4by value, suggesting that this parameter is correlated with other lipids.
社団法人日本循環器学会の論文
1992-08-20