Impact of Decreased Renal Function on Coagulation and Fibrinolysis in Patients With Non-Valvular Atrial Fibrillation
スポンサーリンク
概要
- 論文の詳細を見る
Background: The prothrombotic state in non-valvular atrial fibrillation (NVAF) increases the risk of thromboembolic events. It is also well known that a prothrombotic state exists in renal failure. Hemostatic disorders play a role in thromboembolic mortality in both NVAF and renal failure. However, little is known about the influence of renal function on hemostasis in patients with NVAF. Methods and Results: A total of 190 consecutive outpatients with NVAF who were not receiving anticoagulant therapy were enrolled in the present study. Patients were stratified in groups based on estimated glomerular filtration rate (eGFR). Plasma concentrations of thrombin-antithrombin complex (TAT) and D-dimer were measured and the influence of renal function on coagulation and fibrinolysis was assessed. A relatively weak and inverse relationship of eGFR to TAT and D-dimer was observed (r=0.28, P=0.0001; r=0.30, P<0.0001). Both mean TAT and D-dimer concentrations in groups gradually and significantly increased as eGFR decreased (P<0.0001). On multivariate regression analysis, decreased eGFR concentration was a significant predictor for elevation of TAT (P<0.05) and D-dimer (P<0.01) in patients with NVAF. Conclusions: The enhanced coagulation activation appeared to be related to a reduction in residual renal function in patients with NVAF. This suggests that decreased renal function might be a candidate predictor of thromboembolic events in patients with NVAF. (Circ J 2009; 73: 846 - 850)
- 社団法人 日本循環器学会の論文
- 2009-04-20
著者
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Tanaka Yasuhiro
Department Of Digestive And Life-style Related Diseases Kagoshima University Graduate School Of Medi
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Tanaka Yasuhiro
Department Of Cardiovascular Medicine Tokyo Medical And Dental University
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Kashima Katsuro
Second Department of Cardiology, Kagoshima Medical Center, National Hospital Organization
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Tsubouchi Hirohito
Department of Digestive and Lifestyle-related Diseases, Human Environmental Sciences, Health Researc
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Tsunenari Hiroshi
Department Of Digestive And Life-style Related Diseases Kagoshima University Graduate School Of Medi
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Takei Yasuhiko
Department Of Cardiology Gunma Prefacture Cardiovascukar Center
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Sonoda Masahiro
The Second Department of Cardiology, National Hospital Kyusyu Cardiovascular Center
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Sonoda Masahiro
Second Department Of Cardiology Kagoshima Medical Center National Hospital Organization
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Sonoda Masahiro
2nd Division Of Cardiovascular Medicine National Hospital Organization Kagoshima Medical Center
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Tanaka Hideki
Second Department Of Cardiology Kagoshima Medical Center National Hospital Organization
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Nakamura Kazuhiko
The Second Department of Internal Medicine, Kagoshima University
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Kashima Katsuro
The Second Department of Cardiology, National Hospital Organization Kagoshima Medical Center
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Tanaka Hideki
The Second Department of Cardiology, National Hospital Organization Kagoshima Medical Center
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NURUKI Norihito
Department of Digestive and Life-Style Related Diseases, Kagoshima University Graduate School of Med
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TANAKA Yasuhiro
The Second Department of Cardiology, National Hospital Organization Kagoshima Medical Center
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Nuruki Norihito
Second Department Of Cardiology Kagoshima Medical Center National Hospital Organization
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Sonoda Masahiro
The Second Department Of Cardiology Kyushu Cardiovascular Center
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Kashima Katsuro
Second Department Of Cardiology Kagoshima Medical Center National Hospital Organization
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Nakamura Kazuhiko
The Second Department Of Cardiology Kyushu Cardiovascular Center
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Yuba Takao
Department Of Cardiolgy Tokyo Metropolitan Hiroo General Hospital
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TACHIBANA Hiroki
国立病院九州循環器病センター 第二循環器科
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Tsubouchi Hirohito
Department Of Digestive And Life-style Related Disease Health Research Course Human And Environmenta
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Yamashita Takuya
Division Of Cardiology Gunma Prefectural Cardiovascular Center
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Nakamura Kazuhiko
The Second Cardiovascular Division The National Southern Kyu-syu Central Hospital
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Tanaka Yasuhiro
Division Of 2nd Cardiology National Hospital Organization Kagoshima Medical Center
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Tsubouchi Hirohito
Division Of Cardiology Kagoshima Kouseiren Hospital
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Nakamura Kazuhiko
Institute For Clinical Reseach National Hospital Organization Kyushu Cardiovascular Center
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Saigo Masahiko
2nd Division Of Cardiovascular Medicine National Hospital Organization Kagoshima Medical Center
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Nuruki Norihito
Department Of Digestive And Life-style Related Disease Health Research Course Human And Environmental Sciences Kagoshima University Graduate School Of Medicine And Dental Sciences
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Nuruki Norihito
Department of Cardiology, National Hospital Organization, Kagoshima Medical Center
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TSUBOUCHI Hirohito
Department fo Digestive and Lifestyle-related Disease, Health Research Human and Environnmental Scineces, Kagoshima University Graduate School of Medical and Dental Sciences
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