Hepatic Necrosis with Cholestasis Induced by Long-term Voglibose Administration
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概要
- 論文の詳細を見る
A 76-year-old woman admitted to our hospital for jaundice had been treated for diabetes mellitus with insulin for 9 years and voglibose had been added for the 39 months preceding admission. Elevated serum bilirubin and transaminase concentration began to normalize with initiation of corticosteroid treatment 1 week after discontinuation of voglibose. In the in vitro testing of the patients peripheral blood, lymphocytes showed stimulation by voglibose. In dramatic contrast to an initial liver biopsy specimen that demonstrated cholestasis with submassive and zonal necrosis, the follow-up specimen was normal 1 year later. We believe that patients treated with voglibose should be monitored long-term with monthly determinations of transaminases and bilirubin in serum.(Internal Medicine 40: 484-188, 2001)
- 社団法人 日本内科学会の論文
著者
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ARIMA TERUKATSU
The Second Department of Internal Medicine, Faculty of Medicine, Kagoshima University
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Oketani Makoto
The Second Department Of Internal Medicine Faculty Of Medicine Kagoshima University
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Arima Terukatsu
The Second Department Of Internal Medicine Faculty Of Medicine Kagoshima University
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ARIMA TAKUSHI
The Second Department of Internal Medicine, Faculty of Medicine, Kagoshima University
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KAWAKAMI Shuichi
Takaharu Town Hospital
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HARADA Kouji
the Second Department of Internal Medicine, Kagoshima University
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MIYAZONO Hirotaka
the Second Department of Internal Medicine, Kagoshima University
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MIYAZAKI Hiroomi
the Second Department of Internal Medicine, Kagoshima University
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Miyazaki Hiroomi
The Second Department Of Internal Medicine Kagoshima University
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Arima Takushi
The Second Department Of Internal Medicine Faculty Of Medicine Kagoshima University
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Miyazono Hirotaka
The Second Department Of Internal Medicine Kagoshima University
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Harada Kouji
The Second Department Of Internal Medicine Kagoshima University
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