Morphological Changes of Mitochondria in the Hepatocytes Induced by Administration of a Large Amount of Di (2-ethylhexyl) phthalate (DEHP) to Cynomolgus Monkeys (Macaca fascicularis)
スポンサーリンク
概要
- 論文の詳細を見る
The purpose of this study was to determine the relation between administration of a large amount of Di (2-ethylhexyl) phthalate (DEHP) and peroxisome proliferation in cynomolgus monkey (Macaca fascicularis) hepatocytes. DEHP was administered orally to four cynomolgus monkeys, once daily for 28 days at dose levels of 1,000 and 2,500 mg/kg/day. Enlargement of the mitochondria, and lamellar orientation of the cristae along the major axis of the mitochondria were observed in the hepatocytes; however, we did not observe clear proliferation of peroxisomes.
- 日本毒性病理学会の論文
- 2008-03-25
著者
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OKADA Kosuke
Department of Gastroenterology and Hepatology, Graduate School of Comprehensive Human Sciences, Univ
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Maeda Hiroshi
Shin Nippon Biomedical Laboratories Ltd. Drug Safety Research Laboratories
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Miyajima Hiroaki
Shin Nippon Biomedical Laboratories, Ltd., Japan
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Maeda Hiroshi
Shin Nippon Biomedical Laboratories Ltd.
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SATAKE SHIGERU
Shin Nippon Biomedical Laboratories Ltd.
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Chihaya Yutaka
Shin Nippon Biomedical Laboratories Co. Ltd.
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GORYO Masanobu
Department of Veterinary Pathology, Faculty of Agriculture, Iwate University
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Miyajima Hiroaki
Shin Nippon Biochemical Laboratories Ltd.
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Kamimura Yoshihiro
Shin Nippon Biomedical Laboratories Co. Ltd.
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Okada Kosuke
Department Of Veterinary Pathology Faculty Of Agriculture Iwate University
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Okada Kosuke
Department Of Comparative Pathology Faculty Of Veterinary Medicine Hokkaido University
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Goryo Masanobu
Department Of Comparative Pathology Faculty Of Veterinary Medicine Hokkaido University
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TANIGAWA Youhei
Shin Nippon Biomedical Laboratories Co., Ltd.
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KAMIMURA Yasuhiro
Shin Nippon Biomedical Laboratories Co., Ltd.
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Tanigawa Youhei
Shin Nippon Biomedical Laboratories Co. Ltd.
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Maeda Hiroshi
Shin Nippon Biomedical Laboratories Co. Ltd.
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OKADA KOSUKE
Department of Veterinary Pathology, Faculty of Agriculture, Iwate University
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Satake Shigeru
Shin Nippon Biomedical Laboratories, Ltd.
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Satake Shigeru
Shin Nippon Biomedical Laboratories Co., Ltd.
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GORYO Masanobu
Department of Applied Veterinary Science, United Graduate School of Veterinary Science, Gifu University
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