Parathyroid Hormone Induces Interleukin-6 Gene Expression in Bone Stromal Cells of Young Rats.
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概要
- 論文の詳細を見る
To test the hypothesis that parathyroid hormone (PTH) regulates interleukin-6 (IL-6) expression locally in bone, the expression of IL-6 mRNA was examined by in situ hybridization after a subcutaneous injection of human PTH [1-84] (225 μg/kg) in 4-week old rats. Whereas IL-6 mRNA was not detected at the basal status, it was transiently detected in a subpopulation of stromal cells in the intertrabecular region of the metaphyses from 1/2 to 1 hr after PTH injection. Contrastingly, IL-6 transcripts were not detected in other cell populations at any time points examined. Since IL-6 is a known activator of osteoclasts, these results are consistent with the hypothesis that PTH stimulates the local IL-6 synthesis in stromal cells to indirectly activate osteoclasts.
- 公益社団法人 日本獣医学会の論文
著者
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Segre Gino
Endocirne Unit Massachusetts General Hospital And Department Of Medicine Harvard Medical School
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Lee Kaechoong
Endocirne Unit Massachusetts General Hospital And Department Of Medicine Harvard Medical School
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Chiba Shuichi
Endocrine Unit Massachusetts General Hospital Harvard Medical School
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Okada Kosuke
Department Of Comparative Pathology Faculty Of Veterinary Medicine Hokkaido University
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NEER Robert
Endocrine Unit, Massachusetts General Hospital
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CHIBA Shuichi
Endocrine Unit, Massachusetts General Hospital
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UN-NO Masako
Safety Assessment Laboratory, Chugai Pharmaceutical Co., Ltd.
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