Immunohistochemical Analysis of Expression Patterns of Tumor Necrosis Factor Receptors on Lymphoma Cells in Enzootic Bovine Leukosis
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概要
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Tumor necrosis factor-alpha (TNF-α) has been reported to be associated with the progression of lymphoproliferative neoplastic diseases and retroviral infections. Hence we examined immunohistochemically the expression patterns of TNF-receptors (TNF-RI and RII) on lymphoma cells derived from the 29 cases of enzootic bovine leukosis (EBL). Lymphomas obtained in 29 animals with EBL were histopathologically classified into three types: diffuse mixed type (10 cases), diffuse large type (9 cases), and diffuse large cleaved type (10 cases). Immunohistochemically using a monoclonal antibody to a bovine lymphocyte surface antigen, the lymphomas were classified into three phenotypes: B-1a (CD5+/CD11b+), B-1b (CD5-/CD11b+) and B-2 (conventional B) (CD5-/CD11b-). Interestingly, the lymphoma cells in all animals expressed TNF-RII, but not TNF-RI. Although, in EBL, lymphoma cells of which the histopathological and immunological property differs has been formed, the expression patterns of TNF-Rs had the universality in all lymphoma cells. TNF-RII, which induces cell proliferation, was expressed but TNF-RI, which induces cell apoptosis was not expressed on all lymphoma cells, suggesting that TNF-Rs play an important role in the malignant proliferation of B cells and formation of lymphomas in EBL.
- 公益社団法人 日本獣医学会の論文
著者
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KONNAI Satoru
Laboratory of Infectious Disease, Graduate School of Veterinary Medicine, Hokkaido University
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Okada Kosuke
Department Of Comparative Pathology Faculty Of Veterinary Medicine Hokkaido University
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Onuma Misao
Laboratorie Of Infectious Disease Graduate School Of Veterinary Medicine Hokkaido University
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Ikeda Manabu
Department Of Neuropsychiatry Ehime University Medical School
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GORYO Masanobu
Department of Applied Veterinary Science, United Graduate School of Veterinary Science, Gifu University
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ISHIGURO Naotaka
Department of Pathogenic Veterinary Science, The United Graduate School of Veterinary Sciences, Gifu University
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Ikeda Manabu
Department of Applied Chemistry, Faculty of Engineering, Yokohama National University
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