Passive immunization with monoclonal antibodies : effects on Haemaphysalis longicornis tick infestation of BALB/c mice
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概要
- 論文の詳細を見る
Tick vaccine development plays an important role in current tick control strategies. Previously, we have produced three different isotypes of monoclonal antibodies (mAbs) which recognized a midgut protein of adult Haemaphysalis longicornis. These mAbs, typed as IgG1, 2a, and 2b, reacted with a 76 kDa surface protein of midgut cells. We speculated that the 76 kDa protein may be an unknown antigen for a tick vaccine and the three mAbs may work as probes to clone the protein. In this study, to test whether these three isotypes have anti-tick effects and if so which works more effectively, we conducted passive immunization in BALB/c mice with each of the mAbs, and infested the mice with adult ticks. All isotypes significantly reduced the number of hatched larvae, compared to controls, however, no differences in the magnitude of the reduction were observed among the three.
- 北海道大学の論文
- 2003-02-28
著者
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IWANAGA Toshihiko
Laboratory of Histology and Cytology, Hokkaido University Graduate School of Medicine
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OHASHI Kazuhiko
Laboratory of Infectious Diseases, Granduate School of Veterinary Medicine, Hokkaido University
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ONUMA Misao
Laboratory of Infectious Disease, Graduate School of Veterinary Medicine, Hokkaido University
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Okuma Katashi
Department Of Clinical Laboratory Aichi Cancer Center Hospital
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Ohashi Kazuhiko
Hokkaido Univ. Sapporo Jpn
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Ohashi Kazuhiko
Laboratory Of Infectious Diseases Department Of Disease Control Graduate School Of Veterinary Medici
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Ohashi K
Laboratory Of Infectious Diseases Graduate School Of Veterinary Medicine Hokkaido University
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Iwanaga Toshihiko
Laboratory Of Anatomy Department Of Biomedical Sciences Graduate School Of Veterinary Medicine Hokka
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Iwanaga Toshihiko
Laboratory Of Histology And Cytology Department Of Functional Morphology Graduate School Of Medicine
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Onuma Misao
Laboratorie Of Infectious Disease Graduate School Of Veterinary Medicine Hokkaido University
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Onuma M
Department Of Disease Control Graduate School Of Veterinary Medicine Hokkaido University
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Kodama Michi
Laboratory Of Infectious Diseases Graduate School Of Veterinary Medicine Hokkaido University
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Iwanaga T
Hokkaido Univ. Sapporo
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Nakajima Mie
Laboratory of Infectious Diseases, Graduate School of Veterinary Medicine, Hokkaido University
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Yanase Haruko
Laboratory of Anatomy, Graduate School of Veterinary Medicine, Hokkaido University
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Nakajima Mie
Laboratory Of Infectious Diseases Graduate School Of Veterinary Medicine Hokkaido University
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Yanase H
Laboratory Of Anatomy Graduate School Of Veterinary Medicine Hokkaido University
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Yanase Haruko
Laboratory Of Anatomy Department Of Biomedical Sciences Graduate School Of Veterinary Medicine Hokka
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Iwanaga T
Laboratory Of Histology And Cytology Hokkaido University Graduate School Of Medicine
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Iwanaga Toshihiko
Laboratories Of Anatomy Graduate School Of Veterinary Medicine Hokkaido University
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Ohashi Kazuhiko
Laboratory Of Infectious Disease Graduate School Of Veterinary Medicine Hokkaido University
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