Identification and Characterization of Peptides Binding to Newcastle Disease Virus by Phage Display
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概要
- 論文の詳細を見る
Three individual peptide sequences, EVSHPKVG, WVTTSNQW, and SGGSNRSP, which have potentials to bind to Newcastle disease virus (NDV), were identified by the biopanning method using phage display technology. The binding specificities of these peptides presented on phages were confirmed by ELISA competition assay using chicken anti-NDV antiserum. The synthetic peptides designed based on these results partially neutralized the infection of NDV in vitro. The peptide-motives identified here have the potential to lead to the identification of novel molecules that inhibit the NDV infection independent of the immune system.
- 公益社団法人 日本獣医学会の論文
著者
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Onuma Misao
Laboratorie Of Infectious Disease Graduate School Of Veterinary Medicine Hokkaido University
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Ohashi Kazuhiko
Laboratory Of Infectious Disease Graduate School Of Veterinary Medicine Hokkaido University
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OZAWA Makoto
Laboratory of Infectious Diseases, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University
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