PATHOLOGICAL STUDIES OF MAREK'S DISEASE III ELECTRON MICROSCOPIC OBSERVATION ON DEMYELINATION OF THE PERIPHERAL NERVES

概要

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Degenerative changes of the peripheral nerves in Marek's diseases (MD) were investigated under light and electron microscopy. Three categories of demyelination were classified according to the characteristics of the lesions. Category I was considered as primary demyelination, and it was similar to experimental allergic neuritis. No morphological destruction was seen in the myelin sheath until the mononuclear cells made contact with the myelin within the neurolemma. The attacking mononuclear cells (macrophages) stripped the Schwann cell cytoplasm off the myelin sheath. Category II was considered as Wallerian-like degeneration. Category III was considered as a "hydration" of myelin sheaths due to edema. Myelinolysis, caused by a uniform separation of myelin lamellae in the region of the sub-perineurial edema, was observed independently of MD. The regenerative process, particularly remyelination, was seen in each category. It was suggested that primary demyelination of Category I was the most important phenomena in the pathogenesis of MD nerve lesions.
北海道大学の論文