STUDIES ON INFECTIOUS CANINE HEPATITIS II : HISTOPATHOLOGICAL STUDIES ON EXPERIMENTAL CASES

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The author made histopathological investigation of experimental infectious canine hepatitis and gained the findings stated below. Depending upon clinical symptoms, pathological findings and the results of C.F.T. after inoculation, the following three forms of the disease were demonstrated : 1) fatal severe form, 2) mild and inapparent form, 3) negative from. The fatal severe form is a typical hepatitis and this form is considered as the initial stage of hepatitis. In this form, on the second day after inoculation, MALLORY bodies appeared, and on the fourth day after inoculation, focal necrosis occurred. The location of focal necrosis was not constant and the size of affected areas was small. Central hepatic necrosis, such as in spontaneous cases, was not found in experimental cases. On the fourth day after inoculation, hyaline droplet degeneration, a granulomatous cell proliferation of endothelial cells in the liver was found. The reticular fibers in the liver were intact in almost all cases. In the regressive parts of the liver, decrease or disappearance in PNA were observed, but conversely, R.E.S. cells in the sinusoids were increased in PNA. The characteristic nuclear inclusions of this disease occurred in almost all germinal layers, such as vascular endothelia (mesoderm), adventitial cells, reticulum cells and histiocytes (mesenchyma), liver cells, bronchial epithelia, bile duct epithelia (entoderm), mucosa epithelia in the tonsils (ectoderm), and serosa epithelia in the digestive canals and urinary bladder, epithelia in the heart and epithelia in the adrenal cortex (mesoderm). No inclusion bodies could be seen in the bronchial epithelium and epithelium of membrana nictitans as in spontaneous cases. The occurrence of nuclear inclusions in the ependymal cells was not observed as in experimental cases by GREEN et al. In mild and inapparent form nuclear inclusions were not found. But reactive changes were noticeable, although characteristic changes were not. It appears that recovered cases of H.c.c. take this form and that it corresponds to cases of inapparent infection in spontaneous cases. Pyelitis catarrhalis chronica was especially frequently observed in this experimental cases. In the negative form, no characteristic changes nor reactive changes were observed.
北海道大学の論文
1957-09-25

著者

Fujimoto Yutaka
Department Of Comparative Pathology

STUDIES ON INFECTIOUS CANINE HEPATITIS II : HISTOPATHOLOGICAL STUDIES ON EXPERIMENTAL CASES

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