THE PATHOLOGICAL STUDY OF PARATUBERCULOSIS IN GOATS, CENTERED AROUND THE FORMATION OF REMOTE LESIONS

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A histopathological study was carried out on 45 cases of naturally infected paratuberculosis in goats and following results were obtained : 1) The characteristic lesions of the disease were located mainly in the intestines and the regional lymph nodes. The authors considered the mode of development of the lesions to be spread mainly by way of the lymphatic stream from the intestines and by way of the blood stream. 2) In regard to the remote lesions, characteristic glomerulonephritis, fibrinoid swelling or deposits of amyloid-like substances in the walls of the capillaries and connective tissues, and granulomas in the various parts of the organs and tissues, except the intestines and the mesenteric lymph nodes, were found. 3) Special attention was paid to the pathogenesis of the remote lesions and discussed as the pathological character of the disease. The author eventually emphasized that the disease is not only due to the direct reaction of the M. johnei, but also due to vasculo-mesenchymal tissue reaction (allergic nature) as a systemic disease.
北海道大学の論文